N-[3-(trifluoromethyl)phenyl]pyrazine-2-carboxamide

Base Information

Chemical Name:N-[3-(trifluoromethyl)phenyl]pyrazine-2-carboxamide
CAS No.:81172-86-3
Molecular Formula:C₁₂H₈F₃N₃O
Molecular Weight:267.21
Hs Code.:
NSC Number:131176
DSSTox Substance ID:DTXSID501001824
Wikidata:Q82995838
ChEMBL ID:CHEMBL510601

Synonyms:N-[3-(trifluoromethyl)phenyl]pyrazine-2-carboxamide;81172-86-3;N-(3-Trifluoromethylphenyl)pyrazine-2-carboxamide;NSC131176;MLS000711313;CHEMBL510601;HSMQXQUUMWQMJA-UHFFFAOYSA-N;DTXSID501001824;HMS2633K24;HMS3361L06;STK431950;AKOS001112846;NSC-131176;UPCMLD0ENAT5387270:001;SMR000281080;AB00089666-01;AG-690/08627020;Z28169898;N-[3-(Trifluoromethyl)phenyl]pyrazine-2-carboximidic acid

Suppliers and Price of N-[3-(trifluoromethyl)phenyl]pyrazine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of N-[3-(trifluoromethyl)phenyl]pyrazine-2-carboxamide

Chemical Property:

Vapor Pressure:0.00506mmHg at 25°C
Boiling Point:275.5°C at 760 mmHg
Flash Point:120.4°C
Density:1.419g/cm³
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:267.06194637
Heavy Atom Count:19
Complexity:322

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC(=C1)NC(=O)C2=NC=CN=C2)C(F)(F)F

Technology Process of N-[3-(trifluoromethyl)phenyl]pyrazine-2-carboxamide

There total 2 articles about N-[3-(trifluoromethyl)phenyl]pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19847-10-0
pyrazinoyl chloride

: 98-16-8
3-trifluoromethylaniline

: 81172-86-3
C₁₂H₈F₃N₃O

Guidance literature:: In pyridine; acetone; at 20 ℃; for 0.5h;
DOI:10.1016/j.ejmech.2007.07.013

Reference yield:

: 98-97-5
2-pyrazylcarboxylic acid

: 81172-86-3
C₁₂H₈F₃N₃O

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 20 °C

With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1002/jhet.921