N-[(benzyloxy)carbonyl]glycylglycylalanine

Base Information

• Chemical Name: N-[(benzyloxy)carbonyl]glycylglycylalanine
• CAS No.: 19912-36-8
• Molecular Formula: C₁₅H₁₉N₃O₆
• Molecular Weight: 337.332
• NSC Number: 169111
• DSSTox Substance ID: DTXSID90305091
• Mol file: 19912-36-8.mol

Synonyms:19912-36-8;Z-Gly-Gly-Ala-OH;N-[(benzyloxy)carbonyl]glycylglycylalanine;2-[[2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]acetyl]amino]propanoic acid;NSC169111;SCHEMBL12581559;DTXSID90305091;NSC-169111

Chemical Property of N-[(benzyloxy)carbonyl]glycylglycylalanine

Chemical Property:

• Vapor Pressure: 9.06E-22mmHg at 25°C
• Boiling Point: 720.2 °C at 760 mmHg
• PKA: 3.43±0.10(Predicted)
• Flash Point: 389.4 °C
• PSA: 133.83000
• Density: 1.312 g/cm³
• LogP: 0.79100
• Storage Temp.: -15°C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 9
• Exact Mass: 337.12738533
• Heavy Atom Count: 24
• Complexity: 462

Purity/Quality:

99% ^*data from raw suppliers

Z-Gly-Gly-Ala-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)O)NC(=O)CNC(=O)CNC(=O)OCC1=CC=CC=C1

Technology Process of N-[(benzyloxy)carbonyl]glycylglycylalanine

There total 4 articles about N-[(benzyloxy)carbonyl]glycylglycylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cbz-glycylglycyl hydrazide (3252-83-3) → N-[N-(N-benzyloxycarbonyl-glycyl)-glycyl]-D-alanine (19912-36-8,97466-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous HCl; acetic acid; NaNO₂ / 0 °C

2: aqueous NaOH

With hydrogenchloride; sodium hydroxide; acetic acid; sodium nitrite;

Reference yield:

methyl [({[(benzyloxy)carbonyl]amino}acetyl)amino]acetate (13437-63-3) → N-[N-(N-benzyloxycarbonyl-glycyl)-glycyl]-D-alanine (19912-36-8,97466-06-3)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol; hydrazine hydrate / 20 °C

2: aqueous HCl; acetic acid; NaNO₂ / 0 °C

3: aqueous NaOH

With hydrogenchloride; sodium hydroxide; ethanol; hydrazine hydrate; acetic acid; sodium nitrite;

Reference yield:

D-Alanine (338-69-2,25191-17-7,18875-37-1) + Z-Gly-Gly-N3 (41445-96-9) → N-[N-(N-benzyloxycarbonyl-glycyl)-glycyl]-D-alanine (19912-36-8,97466-06-3)

Guidance literature:

With sodium hydroxide;

upstream raw materials:

D-Alanine

Z-Gly-Gly-N₃

Cbz-glycylglycyl hydrazide

methyl [({[(benzyloxy)carbonyl]amino}acetyl)amino]acetate

Downstream raw materials:

Gly-Gly-dLeu