3252-83-3

Upstream product

• 3005-87-6 Z-Gly-Gly-OEt 
• 13437-63-3 methyl [({[(benzyloxy)carbonyl]amino}acetyl)amino]acetate 
• 64-17-5 ethanol 
• 10084-82-9 N-benzyloxycarbonyl-glycyl=>N-benzyloxycarbonyl-glycyl=>glycine ethyl ester 
• 302-01-2 hydrazine 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 87023-85-6 1-(Cbz-glycyl)-3,5-dimethylpyrazole 
• 1145-81-9 ethyl 2-(benzyloxycarbonylamino)ethanoate 
• 5680-83-1 N-(benzyloxycarbonyl)glycine hydrazide 

Downstream Products

• 41445-96-9 Z-Gly-Gly-N₃ 
• 111195-96-1 [({[(S)-1-(4-Nitro-phenylcarbamoyl)-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamic acid benzyl ester 
• 93726-38-6 1-(Cbz-glycylglycyl)-3,5-dimethylpyrazole 
• 73538-51-9 Z-Gly-Gly-Ser-Pro-OH 
• 19912-36-8 N-[N-(N-benzyloxycarbonyl-glycyl)-glycyl]-D-alanine 
• 859307-62-3 N-benzyloxycarbonyl-glycyl=>glycyl=>glycine phenyl ester 

Relevant academic research and scientific papers

New system for peptide synthesis using N-acylpyrazoles

New system of peptide synthesis was described. The extension of one amino acid unit on the peptide chain was constituted from only 2 reaction steps, the conversion from esters to the corresponding N-acylpyrazoles and the subsequent aminolysis with amino esters. This new system was distinctive from the conventional peptide synthesis, which was consisted of 3 steps of the deprotection, the activation and the condensation. Moreover, the key intermediate N-acylpyrazoles exhibited the excellent properties of high sensitivity and separability for the chiral column on HPLC using the UV detector.