METHYL 5-(2 5-DICHLOROPHENYL)-2-FUROATE&

Base Information

• Chemical Name: METHYL 5-(2 5-DICHLOROPHENYL)-2-FUROATE&
• CAS No.: 480423-60-7
• Molecular Formula: C12H8Cl2O3
• Molecular Weight: 271.1
• Mol file: 480423-60-7.mol

Synonyms:2evm;FC2;5-(2,5-dichlorophenyl)furan-2-carboxylic acid methyl ester;5-(2,5-DICHLOROPHENYL)-2-FUROIC ACID;

Chemical Property of METHYL 5-(2 5-DICHLOROPHENYL)-2-FUROATE&

Chemical Property:

• Melting Point: 88-92 °C(lit.)
• PSA: 39.44000
• LogP: 4.04000

Purity/Quality:

Methyl 5-(2,5-dichlorophenyl)-2-furoate Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 5-(2 5-DICHLOROPHENYL)-2-FUROATE&

There total 2 articles about METHYL 5-(2 5-DICHLOROPHENYL)-2-FUROATE& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

methyl 5-bromo-2-furoate (2527-99-3) + 2,5-dichlorobenzeneboronic acid (135145-90-3) → 5-(2,5-dichlorophenyl)furan-2-carboxylic acid methyl ester (480423-60-7)

Guidance literature:

With barium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 80 ℃; for 12h;

DOI:10.1021/jm0492305

Reference yield:

→ 5-(2,5-dichlorophenyl)furan-2-carboxylic acid methyl ester (480423-60-7)

Guidance literature:

Reference yield:

5-(2,5-dichlorophenyl)furan-2-carboxylic acid methyl ester (480423-60-7) → 5-(2,5-dichlorophenyl)furan-2-carboxylic acid (186830-98-8)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2007.04.022

upstream raw materials:

methyl 5-bromo-2-furoate

2,5-dichlorobenzeneboronic acid

Downstream raw materials:

5-(2,5-dichlorophenyl)furan-2-carboxylic acid

C₁₁H₅Cl₃O₂