6-METHYL-2,2'-BIPYRIDINE

Base Information

• Chemical Name: 6-METHYL-2,2'-BIPYRIDINE
• CAS No.: 56100-22-2
• Molecular Formula: C11H10N2
• Molecular Weight: 170.214
• Hs Code.: 2933399090
• Mol file: 56100-22-2.mol

Synonyms:6-METHYL-2,2'-BIPYRIDINE;6-METHYL-2,2'-DIPYRIDYL

Chemical Property of 6-METHYL-2,2'-BIPYRIDINE

Chemical Property:

• Refractive Index: 1.566
• Boiling Point: 278.6°Cat760mmHg
• PKA: 4.82±0.10(Predicted)
• Flash Point: 104.9°C
• PSA: 25.78000
• Density: 1.06g/cm³
• LogP: 2.45200
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-METHYL-2,2'-BIPYRIDINE

There total 37 articles about 6-METHYL-2,2'-BIPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-bromo-pyridine (109-04-6) + 6-methyl-2-(trifluoromethanesulfonyl)oxypyridine (154447-04-8) → 6-methyl-2,2'-bipyridine (56100-22-2)

Guidance literature:

2-bromo-pyridine; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.5h;

With zinc(II) chloride; In tetrahydrofuran; pentane; at 25 ℃; for 2h;

6-methyl-2-(trifluoromethanesulfonyl)oxypyridine; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; In tetrahydrofuran; pentane; for 18h; Reflux;

DOI:10.15227/orgsyn.078.0051

Reference yield: 85.8%

2-bromo-pyridine (109-04-6) + 2-methyl-6-(tributylstannyl)pyridine (259807-95-9) → 6-methyl-2,2'-bipyridine (56100-22-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In toluene; for 48h; Reflux;

DOI:10.1021/acs.inorgchem.8b00433

Reference yield: 82.0%

[2,2]bipyridinyl (366-18-7) + methyllithium (917-54-4) → 6-methyl-2,2'-bipyridine (56100-22-2)

Guidance literature:

In diethyl ether; at 0 ℃; for 8h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.inorgchem.1c01559

upstream raw materials:

2-bromo-pyridine

2-methylsulfinylpyridine

2-Ethanesulfinyl-6-methyl-pyridine

2-bromo-6-methylpyridine

Downstream raw materials:

C₄₈H₄₈N₆

6-(4-hydroxystyryl)-2,2'-bipyridine