2(5H)-Furanone,5-ethyl-4-hydroxy-5-methyl-3-(1-methylethoxy)-,(5S)-(9CI)

Base Information

Chemical Name:2(5H)-Furanone,5-ethyl-4-hydroxy-5-methyl-3-(1-methylethoxy)-,(5S)-(9CI)
CAS No.:499140-47-5
Molecular Formula:C₁₀H₁₆O₄
Molecular Weight:200.235
Hs Code.:
Mol file:499140-47-5.mol

Synonyms:2(5H)-Furanone,5-ethyl-4-hydroxy-5-methyl-3-(1-methylethoxy)-,(5S)-(9CI)

Suppliers and Price of 2(5H)-Furanone,5-ethyl-4-hydroxy-5-methyl-3-(1-methylethoxy)-,(5S)-(9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2(5H)-Furanone,5-ethyl-4-hydroxy-5-methyl-3-(1-methylethoxy)-,(5S)-(9CI)

Chemical Property:

Boiling Point:327.6±42.0 °C(Predicted)
PKA:5.55±0.10(Predicted)
PSA：55.76000
Density:1.13±0.1 g/cm3(Predicted)
LogP:1.90650

Purity/Quality:

Safty Information:

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Hazard Codes:

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Technology Process of 2(5H)-Furanone,5-ethyl-4-hydroxy-5-methyl-3-(1-methylethoxy)-,(5S)-(9CI)

There total 3 articles about 2(5H)-Furanone,5-ethyl-4-hydroxy-5-methyl-3-(1-methylethoxy)-,(5S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 499140-46-4
(S)-methyl 2-methyl-2-[2-(1-methylethoxy)acetyloxy]butanoate

: 499140-47-5
(S)-5-ethyl-4-hydroxy-5-methyl-3-(1-methylethoxy)-3-oxolen-2-one

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1016/S0040-4020(02)00826-8

Reference yield:

: 37505-07-0
(S)-2-hydroxy-2-methylbutyric acid

: 499140-47-5
(S)-5-ethyl-4-hydroxy-5-methyl-3-(1-methylethoxy)-3-oxolen-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: H₂SO₄ / Heating

2: 80 g / DMAP; DCC; triethylamine / toluene / 30 - 35 °C

3: 91 percent / LiHMDS / tetrahydrofuran / 2 h / -78 °C

With dmap; sulfuric acid; triethylamine; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4020(02)00826-8

Reference yield:

: 208117-20-8
methyl (2S)-2-hydroxy-2-methylbutanoate

: 499140-47-5
(S)-5-ethyl-4-hydroxy-5-methyl-3-(1-methylethoxy)-3-oxolen-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 80 g / DMAP; DCC; triethylamine / toluene / 30 - 35 °C

2: 91 percent / LiHMDS / tetrahydrofuran / 2 h / -78 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4020(02)00826-8