Oxiranecarboxylic acid, 3-phenyl- (9CI)

Base Information

• Chemical Name: Oxiranecarboxylic acid, 3-phenyl- (9CI)
• CAS No.: 5694-02-0
• Molecular Formula: C9H8O3
• Molecular Weight: 164.161
• Hs Code.: 2918990090
• Mol file: 5694-02-0.mol

Synonyms:Oxiranecarboxylic acid, 3-phenyl- (9CI)

Chemical Property of Oxiranecarboxylic acid, 3-phenyl- (9CI)

Chemical Property:

• Boiling Point: 346.8±42.0 °C(Predicted)
• PKA: 3.41±0.40(Predicted)
• PSA: 49.83000
• Density: 1.359±0.06 g/cm3(Predicted)
• LogP: 1.21110

Purity/Quality:

3-Phenyloxirane-2-carboxylic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Oxiranecarboxylic acid, 3-phenyl- (9CI)

There total 8 articles about Oxiranecarboxylic acid, 3-phenyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(E)-3-phenylacrylic acid (140-10-3) → 2,3-epoxy-3-phenylpropanoic acid (5694-02-0)

Guidance literature:

With HOF* CH₃CN;

DOI:10.1016/0040-4039(95)02180-9

Reference yield: 90.0%

Cinnamic acid (621-82-9) → 2,3-epoxy-3-phenylpropanoic acid (5694-02-0)

Guidance literature:

With (2-hydroperoxy-2-methylpropyl)-polysryrene resin; bis(acetylacetonate)oxovanadium; In 1,4-dioxane; at 70 ℃; for 12h;

Reference yield:

(E)-3-phenylpropenal (14371-10-9) → (E)-3-phenylacrylic acid (140-10-3) + benzoic acid (65-85-0,8013-63-6) + 2,3-epoxy-3-phenylpropanoic acid (5694-02-0)

Guidance literature:

upstream raw materials:

2-chloro-3-hydroxy-3-phenyl-propionic acid

(E)-3-phenylpropenal

(E)-3-phenylacrylic acid

ethanol

Downstream raw materials:

diazomethane

methyl (2R,3S)-3-phenylglycidate

methyl 2-hydroxy-3-azido-3-phenylpropionate

benzaldehyde

Refernces

• 1、 Xiu, Zhi-Ming,Wang, Li-Ping,Fu, Jun,Xu, Jia,Liu, Li. "1-Acetyl-5-phenyl-1H-pyrrol-3-ylacetate: An aldose reductase inhibitor for the treatment of diabetic nephropathy". . p. 4482 - 4487. Retrieved 2017/09/12.
• 2、 Sheela,Sreekumar. "Epoxidation and oxidation reactions using divinyl benzene crosslinked polystyrene supported t-butyl hydroperoxide". . p. 943 - 950. Retrieved 2007/10/03.