4,6-Pyrimidinedicarbonitrile (9CI)

Base Information

• Chemical Name: 4,6-Pyrimidinedicarbonitrile (9CI)
• CAS No.: 50844-89-8
• Molecular Formula: C6H2N4
• Molecular Weight: 130.10688
• Hs Code.: 2933599090
• Mol file: 50844-89-8.mol

Synonyms:4,6-Pyrimidinedicarbonitrile (9CI);pyrimidine-4,6-dicarbonitrile

Chemical Property of 4,6-Pyrimidinedicarbonitrile (9CI)

Chemical Property:

• PSA: 73.36000
• LogP: 0.21996
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

Pyrimidine-4,6-dicarbonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-Pyrimidinedicarbonitrile (9CI)

There total 2 articles about 4,6-Pyrimidinedicarbonitrile (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4,6-pyrimidinebis(carboxylic acid amide) → 4,6-dicyanopyrimidine (50844-89-8)

Guidance literature:

With N,N-dimethyl-formamide; trichlorophosphate; for 12.5h; Inert atmosphere; Schlenk technique;

DOI:10.1021/ja4067783

Reference yield:

pyrimidine-4,6-dicarboxylic acid dimethyl ester (6345-43-3) → 4,6-dicyanopyrimidine (50844-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium hydroxide / 2 h / 35 °C / Inert atmosphere; Schlenk technique

2: N,N-dimethyl-formamide; trichlorophosphate / 12.5 h / Inert atmosphere; Schlenk technique

With ammonium hydroxide; N,N-dimethyl-formamide; trichlorophosphate;

DOI:10.1021/ja4067783

upstream raw materials:

pyrimidine-4,6-dicarboxylic acid dimethyl ester

Refernces

• 1、 Shuvaev, Kontantin V.,Tandon, Santokh S.,Dawe, Louise N.,Thompson, Laurence K.. "Unexpected Ni(ii) and Cu(ii) polynuclear assemblies - A balance between ligand and metal ion coordination preferences". . p. 4755 - 4757. Retrieved 2010.