9H-Carbazole-2-carboxylic acid

Base Information

• Chemical Name: 9H-Carbazole-2-carboxylic acid
• CAS No.: 51094-28-1
• Molecular Formula: C13H9NO2
• Molecular Weight: 211.22
• Hs Code.: 2933990090
• ChEMBL ID: CHEMBL1171077
• DSSTox Substance ID: DTXSID80550614
• Wikidata: Q82430036
• Mol file: 51094-28-1.mol

Synonyms:9H-CARBAZOLE-2-CARBOXYLIC ACID;51094-28-1;Carbazol-2-carbonsaure;SCHEMBL147263;CHEMBL1171077;DTXSID80550614;AKOS015967095;EN300-205926

Chemical Property of 9H-Carbazole-2-carboxylic acid

Chemical Property:

• PSA: 53.09000
• LogP: 3.01930
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 211.063328530
• Heavy Atom Count: 16
• Complexity: 292

Purity/Quality:

98% ^*data from raw suppliers

9H-CARBAZOLE-2-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=C(N2)C=C(C=C3)C(=O)O

Technology Process of 9H-Carbazole-2-carboxylic acid

There total 25 articles about 9H-Carbazole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl 9H-carbazole-2-carboxylate (82408-83-1) → 9H-carbazole-2-carboxylic acid (51094-28-1)

Guidance literature:

ethyl 9H-carbazole-2-carboxylate; With sodium hydroxide; In ethanol; water; for 16h; Reflux; Inert atmosphere;

With hydrogenchloride; In ethanol; water; for 1h; Inert atmosphere;

DOI:10.1039/c2ob06868k

Reference yield: 95.0%

methyl 9H-carbazole-2-carboxylate (26000-33-9) → 9H-carbazole-2-carboxylic acid (51094-28-1)

Guidance literature:

With water; sodium hydroxide; In ethanol; for 16h; Reflux;

DOI:10.1016/j.ejmech.2015.11.026

Reference yield: 75.0%

2-amino-[1, 1’-biphenyl]-4-carboxylic acid → 9H-carbazole-2-carboxylic acid (51094-28-1)

Guidance literature:

With 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene hydrochloride; dihydrogen peroxide; palladium diacetate; acetic acid; at 120 ℃; for 0.333333h; Microwave irradiation; Sealed tube;

DOI:10.1002/ejoc.201601191

upstream raw materials:

9H-carbazole-2-carbonitrile

2-acetylcarbazole

methyl 9H-carbazole-2-carboxylate

1-(9H-carbazol-2-yl)-2-chloro-1-ethanone

Downstream raw materials:

N-benzylcarbazole-2-carboxamide

2-aminocarbazole