N-benzylcarbazole-2-carboxamide

Base Information

• Chemical Name: N-benzylcarbazole-2-carboxamide
• CAS No.: 1361925-34-9
• Molecular Formula: C₂₀H₁₆N₂O
• Molecular Weight: 300.36
• Mol file: 1361925-34-9.mol

Synonyms:N-benzylcarbazole-2-carboxamide

Chemical Property of N-benzylcarbazole-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzylcarbazole-2-carboxamide

There total 6 articles about N-benzylcarbazole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

9H-carbazole-2-carboxylic acid (51094-28-1) + benzylamine (100-46-9) → N-benzylcarbazole-2-carboxamide (1361925-34-9)

Guidance literature:

9H-carbazole-2-carboxylic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

benzylamine; In dichloromethane; Inert atmosphere;

DOI:10.1039/c2ob06868k

Reference yield:

ethyl 4-iodo-3-nitrobenzoate (57362-77-3) → N-benzylcarbazole-2-carboxamide (1361925-34-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 18 h / Reflux; Inert atmosphere

2.1: triphenylphosphine / 1,2-dichloro-benzene / Inert atmosphere

3.1: sodium hydroxide / ethanol; water / 16 h / Reflux; Inert atmosphere

3.2: 1 h / Inert atmosphere

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium carbonate; triethylamine; triphenylphosphine; sodium hydroxide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 1,2-dichloro-benzene; 1.1: Suzuki-Miyaura coupling / 2.1: Cadogan reaction;

DOI:10.1039/c2ob06868k

Reference yield:

ethyl 9H-carbazole-2-carboxylate (82408-83-1) → N-benzylcarbazole-2-carboxamide (1361925-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol; water / 16 h / Reflux; Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; sodium hydroxide; In ethanol; dichloromethane; water;

DOI:10.1039/c2ob06868k

upstream raw materials:

9H-carbazole-2-carboxylic acid

benzylamine

4-iodobenzoic acid

4-iodo-3-nitrobenzoic acid