5-BETA-DIHYDRO-17-HYDROXYPROGESTERONE

Base Information

• Chemical Name: 5-BETA-DIHYDRO-17-HYDROXYPROGESTERONE
• CAS No.: 570-58-1
• Molecular Formula: C21H32O3
• Molecular Weight: 332.483
• Mol file: 570-58-1.mol

Synonyms:5-BETA-PREGNAN-17-OL-3,20-DIONE;5BETA-PREGNAN-17ALPHA-OL-3,20-DIONE;5-BETA-DIHYDRO-17-HYDROXYPROGESTERONE;17-alpha-hydroxy-5-beta-pregnane-3,20-dione;17ALPHA-Hydroxy-5B-pregnane-3,20-dione

Chemical Property of 5-BETA-DIHYDRO-17-HYDROXYPROGESTERONE

Chemical Property:

• PSA: 54.37000
• LogP: 3.91830

Purity/Quality:

97% ^*data from raw suppliers

5-BETA-DIHYDRO-17-HYDROXYPROGESTERONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BETA-DIHYDRO-17-HYDROXYPROGESTERONE

There total 9 articles about 5-BETA-DIHYDRO-17-HYDROXYPROGESTERONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

17-hydroxyprogesterone (68-96-2) → 5β-17α-hydroxy-preganene-3,20-dione (570-58-1)

Guidance literature:

With pyridine; palladium 10% on activated carbon; hydrogen; In 1,4-dioxane; ethanol; at 30 ℃; for 17h;

DOI:10.1021/jm501676v

Reference yield:

16α,17-epoxy-5β-pregnane-3,20-dione (974-25-4) → 5β-17α-hydroxy-preganene-3,20-dione (570-58-1)

Guidance literature:

With hydrogen bromide; Hydrieren des Reaktionsprodukts an Palladium/Kohle in Aethanol;

DOI:10.1021/ja01102a006

Reference yield:

16α,17α-epoxyprogesterone (1097-51-4,16356-47-1) → 5β-17α-hydroxy-preganene-3,20-dione (570-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Raney nickel; dioxane; methanol. KOH-solution / Hydrogenation

2: HBr / Hydrieren des Reaktionsprodukts an Palladium/Kohle in Aethanol

With 1,4-dioxane; potassium hydroxide; hydrogen bromide; nickel;

DOI:10.1021/ja01102a006

upstream raw materials:

3α,17-dihydroxy-5β-pregnan-20-one

16α,17-epoxy-5β-pregnane-3,20-dione

5β-pregnene-(17(20)ξ)-diyl-(3α.20)-diacetate

16α,17α-epoxyprogesterone

Downstream raw materials:

5β-dihydro-11-deoxycortisol 21-acetate

hydroxyprogesterone acetate

Refernces