17-ALPHA-HYDROXY-5-ALPHA-PREGNANE-3,20-DIONE

Base Information

• Chemical Name: 17-ALPHA-HYDROXY-5-ALPHA-PREGNANE-3,20-DIONE
• CAS No.: 570-59-2
• Molecular Formula: C21H32O3
• Molecular Weight: 332.483
• Mol file: 570-59-2.mol

Synonyms:5-ALPHA-PREGNAN-17-OL-3,20-DIONE;5ALPHA-PREGNAN-17ALPHA-OL-3,20-DIONE;17-ALPHA-HYDROXY-5-ALPHA-PREGNANE-3,20-DIONE;5A-pregnan-17A-ol-3-20-dione;Allopregnan-17ALPHA-ol-3,20-dione

Chemical Property of 17-ALPHA-HYDROXY-5-ALPHA-PREGNANE-3,20-DIONE

Chemical Property:

• PSA: 54.37000
• LogP: 3.91830

Purity/Quality:

97% ^*data from raw suppliers

5α-Pregnan-17α-ol-3,20-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5alpha-Pregnan-17alpha-ol-3,20-dione is used for enhancing health and physical performance.

Technology Process of 17-ALPHA-HYDROXY-5-ALPHA-PREGNANE-3,20-DIONE

There total 11 articles about 17-ALPHA-HYDROXY-5-ALPHA-PREGNANE-3,20-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

17-hydroxyprogesterone (68-96-2) → 4,5α-dihydro-17α-hydroxyprogesterone (570-59-2)

Guidance literature:

In ethanol; at 24 - 26 ℃; for 96h; Penicillium decumbens ATCC 10436, potato dextrose broth;

DOI:10.1016/0039-128X(95)00071-W

Reference yield:

→ 4,5α-dihydro-17α-hydroxyprogesterone (570-59-2)

Guidance literature:

With pyridine; tert-butyl alcohol; N-bromoacetamide;

DOI:10.1021/ja01165a067

Reference yield:

5α-pregnan-16α,17α-epoxy-3,20-dione (974-24-3) → 4,5α-dihydro-17α-hydroxyprogesterone (570-59-2)

Guidance literature:

With hydrogen bromide; acetic acid; Hydrieren des Reaktionsprodukts an Palladium/BaSO₄ in Aethanol;

upstream raw materials:

17-hydroxy-16β-iodo-5α-pregnane-3,20-dione

5α-pregnan-16α,17α-epoxy-3,20-dione

17-hydroxyprogesterone

3β-acetoxy-5α-pregn-16-en-20-one

Downstream raw materials:

17α-hydroxypregna-1,4-diene-3,20-dione

17-hydroxyprogesterone

Refernces