2,3-Dihydrobenzofuran-6-carbaldehyde

Base Information

• Chemical Name: 2,3-Dihydrobenzofuran-6-carbaldehyde
• CAS No.: 55745-96-5
• Molecular Formula: C9H8O2
• Molecular Weight: 148.15862
• Hs Code.: 2932999099
• European Community (EC) Number: 817-467-9
• Mol file: 55745-96-5.mol

Synonyms:2,3-Dihydrobenzofuran-6-carbaldehyde;55745-96-5;2,3-Dihydro-1-benzofuran-6-carbaldehyde;2,3-dihydro-benzofuran-6-carbaldehyde;6-Benzofurancarboxaldehyde, 2,3-dihydro-;SCHEMBL2416319;XSJAJQSDUJUNAI-UHFFFAOYSA-N;MFCD16658153;AKOS022185364;AS-43827;CS-0139611;EN300-1588074;Z1255367296

Chemical Property of 2,3-Dihydrobenzofuran-6-carbaldehyde

Chemical Property:

• Boiling Point: 268.7 °C at 760 mmHg
• Flash Point: 126.9 °C
• PSA: 26.30000
• Density: 1.222 g/cm³
• LogP: 1.43400
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 148.052429494
• Heavy Atom Count: 11
• Complexity: 156

Purity/Quality:

97% ^*data from raw suppliers

2,3-Dihydrobenzofuran-6-carbaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC2=C1C=CC(=C2)C=O

Technology Process of 2,3-Dihydrobenzofuran-6-carbaldehyde

There total 6 articles about 2,3-Dihydrobenzofuran-6-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 6-bromo-2,3-dihydro-1-benzofuran (189035-22-1) → 2,3-dihydro-1-benzofuran-6-carbaldehyde (55745-96-5)

Guidance literature:

6-bromo-2,3-dihydro-1-benzofuran; With n-butyllithium; In 2-methyltetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

N,N-dimethyl-formamide; In 2-methyltetrahydrofuran; hexane; at -78 ℃; for 2h;

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 1,4-dibromo-2-(2-bromoethoxy)benzene (377091-18-4) → 2,3-dihydro-1-benzofuran-6-carbaldehyde (55745-96-5)

Guidance literature:

1,4-dibromo-2-(2-bromoethoxy)benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 3h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h;

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,3-dihydro-1-benzofuran-6-carbaldehyde (55745-96-5)

Guidance literature:

6-bromo-2,3-dihydro-1-benzofuran; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 - -20 ℃;

With hydrogenchloride; In tetrahydrofuran; hexane; water;

upstream raw materials:

N,N-dimethyl-formamide

6-bromo-2,3-dihydro-1-benzofuran

2,5-dibromofluorobenzene

1,4-dibromo-2-hydroxyethoxybenzene

Downstream raw materials:

(2,3-dihydrobenzofuran-6-yl)methanamine