6-COUMARANMETHYLAMINE

Base Information

• Chemical Name: 6-COUMARANMETHYLAMINE
• CAS No.: 55746-20-8
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.192
• Mol file: 55746-20-8.mol

Synonyms:6-COUMARANMETHYLAMINE;(2,3-Dihydrobenzofuran-6-yl)methanamine

Chemical Property of 6-COUMARANMETHYLAMINE

Chemical Property:

• PSA: 35.25000
• LogP: 1.78050

Purity/Quality:

99%, ^*data from raw suppliers

(2,3-Dihydrobenzofuran-6-yl)methanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-COUMARANMETHYLAMINE

There total 6 articles about 6-COUMARANMETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-((2,3-dihydrobenzofuran-6-yl)methyl)isoindoline-1,3-dione → (2,3-dihydrobenzofuran-6-yl)methanamine (55746-20-8)

Guidance literature:

With hydrazine hydrate; In methanol; at 77 ℃; for 3h;

DOI:10.1016/j.bmc.2015.05.047

Reference yield:

2,3-dihydrobenzofuran-6-formaldehydoxime → (2,3-dihydrobenzofuran-6-yl)methanamine (55746-20-8)

Guidance literature:

With hydrogen; palladium(II) hydroxide; In ethanol; at 30 - 60 ℃; for 6h;

Reference yield:

6-bromo-2,3-dihydro-1-benzofuran (189035-22-1) → (2,3-dihydrobenzofuran-6-yl)methanamine (55746-20-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / -74 - 20 °C / Inert atmosphere

2.1: thionyl chloride / dichloromethane / 1 h / 20 °C / Cooling with ice

2.2: 2 h / 90 °C

3.1: hydrazine hydrate / methanol / 3 h / 77 °C

With thionyl chloride; tert.-butyl lithium; hydrazine hydrate; In tetrahydrofuran; methanol; dichloromethane; pentane;

DOI:10.1016/j.bmc.2015.05.047

upstream raw materials:

6-bromo-2,3-dihydro-1-benzofuran

1,4-dibromo-2-(2-bromoethoxy)benzene

(2,3-dihydrobenzofuran-6-yl)methanol

2,3-dihydro-1-benzofuran-6-carbaldehyde