Acetamide, N-methyl-N-(3S)-3-pyrrolidinyl- (9CI)

Base Information

• Chemical Name: Acetamide, N-methyl-N-(3S)-3-pyrrolidinyl- (9CI)
• CAS No.: 550370-77-9
• Molecular Formula: C7H14N2O
• Molecular Weight: 142.19886
• Mol file: 550370-77-9.mol

Synonyms:Acetamide, N-methyl-N-(3S)-3-pyrrolidinyl- (9CI)

Chemical Property of Acetamide, N-methyl-N-(3S)-3-pyrrolidinyl- (9CI)

Chemical Property:

Purity/Quality:

NLT 98% ^*data from raw suppliers

(S)-3-(N-Acetyl-N-methylamino)pyrrolidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetamide, N-methyl-N-(3S)-3-pyrrolidinyl- (9CI)

There total 2 articles about Acetamide, N-methyl-N-(3S)-3-pyrrolidinyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(tert-butyloxycarbonyl)-3-(N-methylacetamido)pyrrolidine (1160938-28-2,438585-60-5) → (RS)-3-(acetyl-methyl-amino)-pyrrolidine (79286-87-6,550370-77-9,550370-81-5)

Guidance literature:

With hydrogenchloride; In methanol; at 0 - 20 ℃; for 1h;

Reference yield:

1-benzyl-3-(methylamino)pyrrolidine (96568-35-3) → 3-(N-acetyl-N-methylamino)-1-benzylpyrrolidine + (RS)-3-(acetyl-methyl-amino)-pyrrolidine (79286-87-6,550370-77-9,550370-81-5)

Guidance literature:

With acetic anhydride; In palladium-carbon;

Reference yield: 11.0%

N-methyl-N-[(3S)-pyrrolidin-3-yl]acetamide (550370-77-9,550370-81-5) + 4-fluoro-7-methyl-N-((1R)-3-oxocyclohexyl)-1H-indole-2-carboxamide → 4-fluoro-7-methyl-N-((1R,3S)-3-((3S)-3-(N-methylacetamido)pyrrolidin-1-yl)cyclohexyl)-1H-indole-2-carboxamide + 4-fluoro-7-methyl-N-((1R)-3-((3S)-3-(N-methylacetamido)pyrrolidin-1-yl)cyclohexyl)-1H-indole-2-carboxamide

Guidance literature:

N-methyl-N-[(3S)-pyrrolidin-3-yl]acetamide; With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 21 ℃; for 2h;

4-fluoro-7-methyl-N-((1R)-3-oxocyclohexyl)-1H-indole-2-carboxamide; With sodium cyanoborohydride; In methanol; 1,2-dichloro-ethane; at 21 ℃; for 18h;

DOI:10.1021/acsmedchemlett.1c00272

upstream raw materials:

1-benzyl-3-(methylamino)pyrrolidine

1-(tert-butyloxycarbonyl)-3-(N-methylacetamido)pyrrolidine

Refernces

• 1、 -. "Antibacterial 7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivatives". . . Retrieved 2008/06/13.