1198437-75-0

Upstream product

• 1198437-73-8 1-((4-phenyl)sulfonyl)-6-(trimethylstannyl)-1H-indazol-4-amine 
• 55842-53-0 2-methyl-4-thiazolecarbonyl chloride 
• 98-09-9 benzenesulfonyl chloride 
• 35272-15-2 2-methylthiazole-4-carboxylic acid 
• 885518-50-3 6-bromo-1H-indazole-4-amine 
• 1198437-71-6 6-bromo-1-(phenylsulfonyl)-1H-indazol-4-amine 

Downstream Products

• 1198803-99-4 N-{6-[4-(aminosulfonyl)phenyl]-1H-indazol-4-yl}-2-methyl-1,3-thiazole-4-carboxamide 
• 1309778-78-6 2-methyl-N-[6-[3-(methylsulfonyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-thiazole-4-carboxamide 

Relevant academic research and scientific papers

Indazole derivatives for use in the treatment of influenza virus infection

The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection.

Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease

Optimization of lead compound 1, through extensive use of structure-based design and a focus on PI3Kδ potency, isoform selectivity, and inhaled PK properties, led to the discovery of clinical candidates 2 (GSK2269557) and 3 (GSK2292767) for the treatment of respiratory indications via inhalation. Compounds 2 and 3 are both highly selective for PI3Kδ over the closely related isoforms and are active in a disease relevant brown Norway rat acute OVA model of Th2-driven lung inflammation.

NOVEL COMPOUNDS

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.

INDAZOLE DERIVATIVES AS PI 3 - KINASE INHIBITORS

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.

4-CARBOXAMIDE INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF P13-KINASES

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of P13-kinase activity.

BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.