5-[4-(trifluoromethyl)phenyl]furan-2-carboxylic Acid

Base Information

Chemical Name:5-[4-(trifluoromethyl)phenyl]furan-2-carboxylic Acid
CAS No.:55377-78-1
Molecular Formula:C₁₂H₇F₃O₃
Molecular Weight:256.181
Hs Code.:2932190090
DSSTox Substance ID:DTXSID30382240
Wikidata:Q82173551
ChEMBL ID:CHEMBL4177369
Mol file:55377-78-1.mol

Synonyms:55377-78-1;5-[4-(trifluoromethyl)phenyl]furan-2-carboxylic Acid;5-(4-(Trifluoromethyl)phenyl)furan-2-carboxylic acid;2-Furancarboxylic acid, 5-[4-(trifluoromethyl)phenyl]-;MFCD06739573;5-(4-trifluoromethylphenyl)-furan-2-carboxylic acid;5-[4-(Trifluoromethyl)phenyl]furan-2-carboxylicAcid;SCHEMBL3744237;CHEMBL4177369;DTXSID30382240;NFALWHMESUMVKK-UHFFFAOYSA-N;AKOS004113996;SB61277;AS-43333;SY032592;5-[4-(trifluoromethyl)phenyl]2-furoic acid;BB 0220520;CS-0231646;5-[4-(trifluoromethyl)phenyl]-2-furoic acid;EN300-109251;A870207;5-(4-Trifluoromethyl-phenyl)-furan-2-carboxylic acid;Z385050404;5-(4-Trifluoromethyl-phenyl)-furan-2-carboxylic acid, AldrichCPR

Suppliers and Price of 5-[4-(trifluoromethyl)phenyl]furan-2-carboxylic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Oakwood
5-(4-Trifluoromethyl-phenyl)-furan-2-carboxylicacid
1g
$ 450.00

Crysdot
5-(4-(Trifluoromethyl)phenyl)furan-2-carboxylicacid 95+%
5g
$ 523.00

Chemenu
5-(4-(Trifluoromethyl)phenyl)furan-2-carboxylicacid 95%
5g
$ 489.00

American Custom Chemicals Corporation
5-[4-(TRIFLUOROMETHYL)PHENYL]2-FUROIC ACID 95.00%
1G
$ 1091.48

Alichem
5-(4-(Trifluoromethyl)phenyl)furan-2-carboxylicacid
1g
$ 257.00

AK Scientific
5-(4-(Trifluoromethyl)phenyl)furan-2-carboxylicacid
5g
$ 766.00

Total 17 raw suppliers

Chemical Property of 5-[4-(trifluoromethyl)phenyl]furan-2-carboxylic Acid

Chemical Property:

PSA：50.44000
LogP:3.66360
Storage Temp.:2-8°C
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:256.03472857
Heavy Atom Count:18
Complexity:308

Purity/Quality:

97% ^*data from raw suppliers

5-(4-Trifluoromethyl-phenyl)-furan-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CC=C(O2)C(=O)O)C(F)(F)F

Technology Process of 5-[4-(trifluoromethyl)phenyl]furan-2-carboxylic Acid

There total 5 articles about 5-[4-(trifluoromethyl)phenyl]furan-2-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

: 55377-78-1
5-(4-(trifluoromethyl)phenyl)furan-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / neat (no solvent) / 0.08 h

2: palladium(II) acetylacetonate; johnphos; caesium carbonate; tetrabutyl-ammonium chloride / N,N-dimethyl-formamide / 0.13 h / 170 °C / Microwave irradiation

3: tetrakis(actonitrile)copper(I) hexafluorophosphate; dmap; oxygen / dichloromethane / 6 h / 20 °C / 760.05 Torr / Molecular sieve; Sealed tube; Schlenk technique

4: sodium dihydrogenphosphate; sodium chlorite; dihydrogen peroxide / acetonitrile; water / 18 h / 20 °C / Darkness

With dmap; sodium chlorite; sodium dihydrogenphosphate; tetrakis(actonitrile)copper(I) hexafluorophosphate; tetrabutyl-ammonium chloride; dihydrogen peroxide; oxygen; palladium(II) acetylacetonate; caesium carbonate; potassium hydroxide; johnphos; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.joc.0c02236

Reference yield:

: 6338-41-6
5-hydroxymethyl-furan-2-carboxylic acid

: 55377-78-1
5-(4-(trifluoromethyl)phenyl)furan-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: palladium(II) acetylacetonate; johnphos; caesium carbonate; tetrabutyl-ammonium chloride / N,N-dimethyl-formamide / 0.13 h / 170 °C / Microwave irradiation

2: tetrakis(actonitrile)copper(I) hexafluorophosphate; dmap; oxygen / dichloromethane / 6 h / 20 °C / 760.05 Torr / Molecular sieve; Sealed tube; Schlenk technique

3: sodium dihydrogenphosphate; sodium chlorite; dihydrogen peroxide / acetonitrile; water / 18 h / 20 °C / Darkness

With dmap; sodium chlorite; sodium dihydrogenphosphate; tetrakis(actonitrile)copper(I) hexafluorophosphate; tetrabutyl-ammonium chloride; dihydrogen peroxide; oxygen; palladium(II) acetylacetonate; caesium carbonate; johnphos; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.joc.0c02236

Reference yield:

: 476155-29-0
{5-[4-(trifluoromethyl)phenyl]furan-2-yl}methanol

: 55377-78-1
5-(4-(trifluoromethyl)phenyl)furan-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(actonitrile)copper(I) hexafluorophosphate; dmap; oxygen / dichloromethane / 6 h / 20 °C / 760.05 Torr / Molecular sieve; Sealed tube; Schlenk technique

2: sodium dihydrogenphosphate; sodium chlorite; dihydrogen peroxide / acetonitrile; water / 18 h / 20 °C / Darkness

With dmap; sodium chlorite; sodium dihydrogenphosphate; tetrakis(actonitrile)copper(I) hexafluorophosphate; dihydrogen peroxide; oxygen; In dichloromethane; water; acetonitrile;
DOI:10.1021/acs.joc.0c02236