2-(4-FLUOROBENZOYL)-3-PHENYLOXIRANE 98

Base Information

• Chemical Name: 2-(4-FLUOROBENZOYL)-3-PHENYLOXIRANE 98
• CAS No.: 51477-11-3
• Molecular Formula: C₁₅H₁₁FO₂
• Molecular Weight: 242.25
• Hs Code.: 2914790090
• Mol file: 51477-11-3.mol

Synonyms:2-(4-FLUOROBENZOYL)-3-PHENYLOXIRANE 98;2-(4-Fluorobenzoyl)-3-phenyloxirane 98%

Chemical Property of 2-(4-FLUOROBENZOYL)-3-PHENYLOXIRANE 98

Chemical Property:

• Melting Point: 88-89
• Refractive Index: 1.6
• Boiling Point: 386.5°Cat760mmHg
• Flash Point: 181.1°C
• PSA: 29.60000
• Density: 1.277g/cm³
• LogP: 3.14850

Purity/Quality:

98%Min ^*data from raw suppliers

2-(4-FLUOROBENZOYL)-3-PHENYLOXIRANE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-FLUOROBENZOYL)-3-PHENYLOXIRANE 98

There total 8 articles about 2-(4-FLUOROBENZOYL)-3-PHENYLOXIRANE 98 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 4-fluorobenzaldehyde (459-57-4) → (4-fluorophenyl)(3-phenyloxiran-2-yl)methanone (73936-27-3,51477-11-3)

Guidance literature:

With dipotassium peroxodisulfate; methylene blue; potassium carbonate; In water; at 25 ℃; for 12h; Irradiation; Green chemistry;

DOI:10.1021/acs.joc.8b01026

Reference yield: 81.0%

(E)-1-(4-fluorophenyl)-3-phenyl-2-propen-1-one (22966-25-2) → trans-2,3-epoxy-1-(4-fluorophenyl)-3-phenylpropan-1-one (51477-11-3,73936-27-3)

Guidance literature:

With potassium hydroxide; trichloroisocyanuric acid; tetrabutylammomium bromide; In toluene; at 10 ℃; for 5h;

DOI:10.1002/adsc.200303227

Reference yield:

4'-fluorochalcone (399-10-0) → (4-fluorophenyl)(3-phenyloxiran-2-yl)methanone (73936-27-3,51477-11-3)

Guidance literature:

With dihydrogen peroxide; Alkaline solution; Inert atmosphere;

DOI:10.1016/j.tet.2012.04.047

upstream raw materials:

4'-fluorochalcone

benzaldehyde

1-(4-fluorophenyl)ethanone

styrene

Downstream raw materials:

3-Bromo-1-(4-fluoro-phenyl)-2-hydroxy-3-phenyl-propan-1-one

(4-fluorophenyl)phenylethanedione

1,1'-diethylstilbene

Refernces

• 1、 Jurczak, Janusz,Majdecki, Maciej,Tyszka-Gumkowska, Agata. "Highly Enantioselective Epoxidation of α,β-Unsaturated Ketones Using Amide-Based Cinchona Alkaloids as Hybrid Phase-Transfer Catalysts". supporting information. . Retrieved 2020/11/13.
• 2、 Huang, Qiang,Wu, Ji-Wei,Xu, Hua-Jian. "Biomimetic hydrogenation: A reusable NADH co-enzyme model for hydrogenation of α,β-epoxy ketones and 1,2-diketones". supporting information. p. 3877 - 3881. Retrieved 2013/07/05.