ethyl 4-cyclohexylbutanoate

Base Information

• Chemical Name: ethyl 4-cyclohexylbutanoate
• CAS No.: 17851-38-6
• Molecular Formula: C12H22 O2
• Molecular Weight: 198.305
• Mol file: 17851-38-6.mol

Synonyms:Cyclohexanebutyricacid, ethyl ester (7CI,8CI); Ethyl 4-cyclohexylbutanoate; Ethyl4-cyclohexylbutyrate; NSC 404925

Chemical Property of ethyl 4-cyclohexylbutanoate

Chemical Property:

• Vapor Pressure: 0.0237mmHg at 25°C
• Boiling Point: 248.9°C at 760 mmHg
• Flash Point: 100.5°C
• Density: 0.928g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 4-cyclohexylbutanoate

There total 10 articles about ethyl 4-cyclohexylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

ethyl 4-iodobutyrate (7425-53-8) + dicyclohexylzinc(II) (15658-08-9) → ethyl 4-cyclohexylbutanoate (17851-38-6)

Guidance literature:

With para-fluorostyrene; tetra-(n-butyl)ammonium iodide; bis(acetylacetonate)nickel(II); In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at -30 ℃; for 16h;

DOI:10.1021/jo0105787

Reference yield: 31.0%

Ethyl 4-bromobutyrate (2969-81-5) + potassium [18-crown-6] bis(catecholato)cyclohexylsilicate → diethyl suberate (2050-23-9) + ethyl 4-cyclohexylbutanoate (17851-38-6)

Guidance literature:

With [2,2]bipyridinyl; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; Ir(dF(CF₃)ppy)2(bpy)PF₆; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1002/ejoc.201601571

Reference yield:

ethyl 3-benzoylpropanoate (6270-17-3) → ethyl 4-cyclohexylbutanoate (17851-38-6)

Guidance literature:

With hydrogen; nickel; In ethanol; at 120 - 130 ℃; under 38000 Torr;

upstream raw materials:

ethanol

4-cyclohexylbutanoic acid

4-cyclohexyl-4-oxo-butyric acid ethyl ester

ethyl 4-iodobutyrate

Downstream raw materials:

(2-cyclohexyl-ethyl)-oxalacetic acid diethyl ester

ethyl 2-R-hydroxy-4-cyclohexylbutyrate

ethyl 4-cyclohexyl-2-oxo-butyrate

ethyl 4-cyclohexyl-2-(methoxyimino)butanoate