H-D-Lys(AC)-OH

Base Information

• Chemical Name: H-D-Lys(AC)-OH
• CAS No.: 51621-57-9
• Molecular Formula: C8H16N2O3
• Molecular Weight: 188.22
• DSSTox Substance ID: DTXSID70426374
• Nikkaji Number: J2.587.064F
• Mol file: 51621-57-9.mol

Synonyms:H-D-LYS(AC)-OH;51621-57-9;(2R)-6-acetamido-2-aminohexanoic acid;(R)-6-Acetamido-2-aminohexanoic acid;(2R)-6-acetamido-2-azaniumylhexanoate;Nepsilon-Acetyl-D-lysine;N6-acetyl-D-lysine;D-Lys(Ac)-OH;N~6~-Acetyl-D-lysine;SCHEMBL919222;DTXSID70426374;MFCD00237141;(R)-6-Acetamido-2-aminohexanoicacid;AKOS006274205;AS-56573;(2R)-2-AMINO-6-ACETAMIDOHEXANOIC ACID;F10914;EN300-7360978

Chemical Property of H-D-Lys(AC)-OH

Chemical Property:

• Melting Point: 252 °C
• Boiling Point: 442.0±40.0 °C(Predicted)
• PKA: 2.53±0.24(Predicted)
• PSA: 92.42000
• Density: 1.139±0.06 g/cm3(Predicted)
• LogP: 0.79590
• Storage Temp.: Store at 0-5°C
• XLogP3: -2.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 188.11609238
• Heavy Atom Count: 13
• Complexity: 182

Purity/Quality:

97% ^*data from raw suppliers

H-D-Lys(ac)-oh ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NCCCCC(C(=O)O)N
• Isomeric SMILES: CC(=O)NCCCC[C@H](C(=O)O)N

Technology Process of H-D-Lys(AC)-OH

There total 1 articles about H-D-Lys(AC)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-acetyl-N-methoxyacetamide (128459-09-6) + L-lysine (56-87-1,70-54-2,923-27-3,6899-06-5,60103-30-2,60132-27-6,3506-25-0) → Nε-Ac-L-Lys (692-04-6,1071-49-4,51621-57-9)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; for 15.5h; Ambient temperature;

DOI:10.1016/S0040-4039(00)94382-X

Reference yield: 56.0%

Nε-acetyl-lysine (51621-57-9) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → D-Nα-Fmoc-AcK (320410-22-8)

Guidance literature:

Nε-acetyl-lysine; N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; With sodium carbonate; In 1,4-dioxane; water; at 20 ℃;

With hydrogenchloride; water; at 0 ℃; pH=1;

DOI:10.1016/j.bioorg.2009.10.001

Reference yield:

(3R,4R)-1-(4-fluorophenyl)-3-[(4-fluorobenzoyl)methylthio]-4-{4-[N-(carboxymethyl)carbamoylmethoxy]phenyl}azetidin-2-one (858104-55-9) + Nε-acetyl-lysine (51621-57-9) → C35H36F2N4O8S

Guidance literature:

With 4-methyl-morpholine; (1,1,1-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; N,N-dimethyl-formamide; In dichloromethane; at 30 ℃; for 1.5h;

upstream raw materials:

N-acetyl-N-methoxyacetamide

L-lysine

Downstream raw materials:

D-Nα-Fmoc-AcK