4-Methoxy-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-G]isoquinoline

Base Information

Chemical Name:4-Methoxy-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-G]isoquinoline
CAS No.:5263-78-5
Molecular Formula:C11H13NO3
Molecular Weight:207.23
Hs Code.:2934999090
DSSTox Substance ID:DTXSID40552376
Wikidata:Q82432578
Mol file:5263-78-5.mol

Synonyms:4-METHOXY-5,6,7,8-TETRAHYDRO-[1,3]DIOXOLO[4,5-G]ISOQUINOLINE;5263-78-5;SCHEMBL10430667;DTXSID40552376;AKOS026669998;4-Methoxy-5,6,7,8-tetrahydro-2H-[1,3]dioxolo[4,5-g]isoquinoline

Suppliers and Price of 4-Methoxy-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-G]isoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-METHOXY-5,6,7,8-TETRAHYDRO-[1,3]-DIOXOLO-[4,5-G]ISOQUINOLINE 95.00%
5MG
$ 503.50

Total 5 raw suppliers

Chemical Property of 4-Methoxy-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-G]isoquinoline

Chemical Property:

PSA：39.72000
LogP:1.39840
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:207.08954328
Heavy Atom Count:15
Complexity:236

Purity/Quality:

97% ^*data from raw suppliers

4-METHOXY-5,6,7,8-TETRAHYDRO-[1,3]-DIOXOLO-[4,5-G]ISOQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C2CNCCC2=CC3=C1OCO3

Technology Process of 4-Methoxy-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-G]isoquinoline

There total 9 articles about 4-Methoxy-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-G]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 4-Methoxy-1,3-dioxolo<4,5-g>5,6,7,8-tetrahydroisochinolin-8-ol-Hydrochlorid

: 5263-78-5
5,6,7,8-Tetrahydro-4-methoxy-1,3-dioxolo<4,5-g>isoquinoline

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; for 24h; under 26252.1 Torr;
DOI:10.1007/BF00809970

Reference yield: 67.0%

: 484-30-0
4-Methoxy-1,3-dioxolo<4,5-g>7,8-dihydroisochinolin

: 5263-78-5
5,6,7,8-Tetrahydro-4-methoxy-1,3-dioxolo<4,5-g>isoquinoline

Guidance literature:: With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 18h;

Reference yield:

: 5779-99-7
4-methoxybenzo[d][1,3]dioxole-5-carbaldehyde

: 5263-78-5
5,6,7,8-Tetrahydro-4-methoxy-1,3-dioxolo<4,5-g>isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / H₂ / 5percent Pd-C / methanol / 2 h / Ambient temperature

2: 1) 6N HCl, 2) H₂ / 2) 5percent Pd-C / 1)r.t., 4 d, 2) r.t.

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1021/jo00299a016