(R)-(+)-1-(2-Naphthyl)ethanol

Base Information

• Chemical Name: (R)-(+)-1-(2-Naphthyl)ethanol
• CAS No.: 52193-85-8
• Molecular Formula: C12H12O
• Molecular Weight: 172.227
• Hs Code.: 2906299090
• DSSTox Substance ID: DTXSID50426276
• Nikkaji Number: J53.214B
• Wikidata: Q72493741
• ChEMBL ID: CHEMBL206560
• Mol file: 52193-85-8.mol

Synonyms:52193-85-8;(R)-(+)-1-(2-Naphthyl)ethanol;(R)-(+)-alpha-Methyl-2-naphthalenemethanol;(R)-1-(Naphthalen-2-yl)ethanol;(1R)-1-naphthalen-2-ylethanol;(R)-1-(2-naphthyl)ethanol;CHEMBL206560;(1R)-1-(naphthalen-2-yl)ethan-1-ol;MFCD00075344;SCHEMBL445001;DTXSID50426276;AXRKCRWZRKETCK-SECBINFHSA-N;BDBM50183596;(+)-(R)-1-Naphthalen-2-ylethanol;AKOS012670050;AKOS015840846;(R)-(+)-2-(1-Hydroxyethyl)naphthalene;AS-60197;(R)-(+)-1-(2-Naphthyl)ethanol, 98%;CS-0085781;FT-0772654;N0784;EN300-85075;T72566

Chemical Property of (R)-(+)-1-(2-Naphthyl)ethanol

Chemical Property:

• Vapor Pressure: 0.000177mmHg at 25°C
• Melting Point: 68-70 °C(lit.)
• Refractive Index: 1.632
• Boiling Point: 316°Cat760mmHg
• Flash Point: 145.4°C
• PSA: 20.23000
• Density: 1.113g/cm³
• LogP: 2.89310
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol,Toluene
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 172.088815002
• Heavy Atom Count: 13
• Complexity: 167

Purity/Quality:

99.5% ^*data from raw suppliers

(R)-(+)-1-(2-Naphthyl)ethanol ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC2=CC=CC=C2C=C1)O
• Isomeric SMILES: C[C@H](C1=CC2=CC=CC=C2C=C1)O
• Uses: (R)-(+)-1-(2-Naphthyl)ethanol may be used to synthesize (S)-2-chloro-1-phenylethanol by reacting with 2-chloroacetophenone in the presence of a chiral bidentate titanium Lewis acid catalyst.

Technology Process of (R)-(+)-1-(2-Naphthyl)ethanol

There total 121 articles about (R)-(+)-1-(2-Naphthyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-(2-naphthyl)ethanol (7228-47-9) → (S)-1-(2-Naphthyl)ethanol (27544-18-9) + (R)-1-(2-Naphthyl)ethanol (52193-85-8) + methyl 2-naphthyl ketone (93-08-3)

Guidance literature:

With (1R)-N-oxyl-1-(N-benzylcarbamoyl)-8-azabicyclo[3.2.1]octane; sodium hydrogencarbonate; sodium bromide; In dichloromethane; water; at 0 ℃; optical yield given as %ee; enantioselective reaction; Electrochemical reaction;

DOI:10.1016/j.tetasy.2008.12.011

Reference yield: 46.0%

2-(2-naphthyl)ethanol (7228-47-9) → (R)-1-(2-Naphthyl)ethanol (52193-85-8) + methyl 2-naphthyl ketone (93-08-3)

Guidance literature:

With α-naphthol; C₁₃₆H₁₀₂Fe₂N₄O₆; In toluene; at 50 ℃; for 18h; optical yield given as %ee;

DOI:10.1021/ja204426s

Reference yield:

2-ethylnaphthalene (939-27-5) → (S)-1-(2-Naphthyl)ethanol (27544-18-9) + (R)-1-(2-Naphthyl)ethanol (52193-85-8) + methyl 2-naphthyl ketone (93-08-3)

Guidance literature:

With iodosylbenzene; iron(III) meso-tetraphenylporhinato chloride; In dichloromethane; at 0 ℃; for 1h; Yield given. Yields of byproduct given;

DOI:10.1021/jo00298a046

upstream raw materials:

2-ethylnaphthalene

2-(2-naphthyl)ethanol

1-(2-naphthyl)ethyl acetate

methyl magnesium iodide

Downstream raw materials:

[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid (R)-1-naphthalen-2-yl-ethyl ester

2-(2-naphthyl)ethanol

methyl 2-naphthyl ketone

(S)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-naphthalen-2-yl-dithiopropionic acid methyl ester