Acetamide, N-(2-methyl-1H-benzimidazol-5-yl)- (9CI)

Base Information

• Chemical Name: Acetamide, N-(2-methyl-1H-benzimidazol-5-yl)- (9CI)
• CAS No.: 56842-62-7
• Molecular Formula: C10H11N3O
• Molecular Weight: 189.21384
• Mol file: 56842-62-7.mol

Synonyms:Acetamide, N-(2-methyl-1H-benzimidazol-5-yl)- (9CI)

Chemical Property of Acetamide, N-(2-methyl-1H-benzimidazol-5-yl)- (9CI)

Chemical Property:

• PSA: 57.78000
• LogP: 1.90270

Purity/Quality:

N-(2-METHYL-1H-BENZIMIDAZOL-5-YL)ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetamide, N-(2-methyl-1H-benzimidazol-5-yl)- (9CI)

There total 15 articles about Acetamide, N-(2-methyl-1H-benzimidazol-5-yl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.5%

acetic acid (64-19-7,77671-22-8) + 2,4-Dinitroanilin (97-02-9) → 5-acetamido-2-methylbenzimidazole (56842-62-7)

Guidance literature:

acetic acid; 2,4-Dinitroanilin; With hydrogen; palladium on activated charcoal; at 60 - 65 ℃; for 4h; under 30402 Torr;

for 6h; Further stages.; Heating;

DOI:10.1007/s11172-007-0184-z

Reference yield:

2-methyl-5-nitrobenzimidazole (1792-40-1) → 5-acetamido-2-methylbenzimidazole (56842-62-7)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Raney nickel / ethanol

2: pyridine / dimethylformamide / Ambient temperature

With pyridine; hydrogen; nickel; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00350a002

Reference yield:

5-amino-2-methylbenzimidazole (29043-48-9) + acetyl chloride (75-36-5) → 5-acetamido-2-methylbenzimidazole (56842-62-7)

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jm00350a002

upstream raw materials:

1,2,4-triaminobenzene N¹,N²,N⁴-triacetate

acetic anhydride

5-amino-2-methylbenzimidazole

acetyl chloride

Refernces

• 1、 Murray, Michael,Ryan, Adrian J.,Little, Peter J.. "Inhibition of Rat Hepatic Microsomal Aminopyrine N-Demethylase Activity by Benzimidazole Derivatives. Quantitative Structure-Activity Relationships". . p. 887 - 892. Retrieved 2007/10/02.