2-Amino-3-benzoyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

Base Information

• Chemical Name: 2-Amino-3-benzoyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine
• CAS No.: 57226-72-9
• Molecular Formula: C14H14N2OS
• Molecular Weight: 258.344
• ChEMBL ID: CHEMBL62199
• DSSTox Substance ID: DTXSID801159521
• Nikkaji Number: J1.385.122K
• Mol file: 57226-72-9.mol

Synonyms:2-amino-3-benzoyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine;57226-72-9;CHEMBL62199;SCHEMBL5512688;CQQSPRAGMLYQRC-UHFFFAOYSA-N;DTXSID801159521;AKOS014690196;2-amino-3-benzoyl4,5,6,7-tetrahydrothieno[2,3-c]pyridine;(2-Amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-3-yl)phenylmethanone

Chemical Property of 2-Amino-3-benzoyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

Chemical Property:

• PSA: 83.36000
• LogP: 3.11700
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 258.08268425
• Heavy Atom Count: 18
• Complexity: 317

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CNCC2=C1C(=C(S2)N)C(=O)C3=CC=CC=C3

Technology Process of 2-Amino-3-benzoyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

There total 4 articles about 2-Amino-3-benzoyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

→ 2-amino-3-benzoyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine (57226-72-9)

Guidance literature:

Reference yield: 58.0%

2-Amino-3-benzoyl-6-benzyloxycarbonyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine (223423-21-0) → 2-amino-3-benzoyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine (57226-72-9)

Guidance literature:

With hydrogen bromide; acetic acid; at 20 ℃; for 6h;

DOI:10.1016/S0960-894X(00)00379-6

Reference yield:

Benzoylacetonitrile (614-16-4) → 2-amino-3-benzoyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine (57226-72-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / sulfur; morpholine / ethanol / 1 h / 70 °C

2: 58 percent / HBr; AcOH / 6 h / 20 °C

With morpholine; hydrogen bromide; sulfur; acetic acid; In ethanol; 1: Cyclization / 2: Acidolysis;

DOI:10.1016/S0960-894X(00)00379-6

upstream raw materials:

2-Amino-3-benzoyl-6-benzyloxycarbonyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine

Benzoylacetonitrile

α-bromoacetophenone