2-chloro-N-ethylnicotinamide

Base Information

• Chemical Name: 2-chloro-N-ethylnicotinamide
• CAS No.: 52943-22-3
• Molecular Formula: C8H9ClN2O
• Molecular Weight: 184.62
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID80429376
• Nikkaji Number: J2.592.691I
• Mol file: 52943-22-3.mol

Synonyms:2-chloro-N-ethylnicotinamide;52943-22-3;2-chloro-N-ethylpyridine-3-carboxamide;2-Chloro-N-ethyl-nicotinamide;SCHEMBL13702282;DTXSID80429376;ethyl 2-chloro-3-pyridinecarboxamide;MFCD01358076;AKOS000159292;SB54143;2-Chloro-N-ethylnicotinamide, AldrichCPR;BB 0216630;CS-0131930;EN300-51174;Z32024438

Chemical Property of 2-chloro-N-ethylnicotinamide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.54
• Boiling Point: 340.736 °C at 760 mmHg
• Flash Point: 159.872 °C
• PSA: 41.99000
• Density: 1.219 g/cm³
• LogP: 1.87560
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 184.0403406
• Heavy Atom Count: 12
• Complexity: 163

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-N-ethylnicotinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNC(=O)C1=C(N=CC=C1)Cl

Technology Process of 2-chloro-N-ethylnicotinamide

There total 1 articles about 2-chloro-N-ethylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-chloro-N-ethylpyridine-3-carboxamide (52943-22-3)

Guidance literature:

2-Chlornicotinsaeure, 1. SOCl2, 2. EtNH2;

Reference yield: 84.0%

2-chloro-N-ethylpyridine-3-carboxamide (52943-22-3) + 1-isothiocyanato-2-methoxybenzene (3288-04-8) → 3-ethyl-2-(2-methoxyphenylimino)-2,3-dihydropyrido[3,2-e]-1,3-thiazin-4-one

Guidance literature:

2-chloro-N-ethylpyridine-3-carboxamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil;

1-isothiocyanato-2-methoxybenzene; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

DOI:10.3987/COM-08-11593

Reference yield: 80.0%

1-bromo-2-naphthol (573-97-7) + 2-chloro-N-ethylpyridine-3-carboxamide (52943-22-3) → C18H14N2O2

Guidance literature:

With copper(I) oxide; caesium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 3h;

DOI:10.1039/c4ra11128a

Downstream raw materials:

ethyl 2-(3-trifluoromethylphenylamino)-3-pyridinecarboxamide