2-Fluorobiphenyl-4-carboxaldehyde

Base Information

Chemical Name:2-Fluorobiphenyl-4-carboxaldehyde
CAS No.:57592-43-5
Molecular Formula:C6H5C6H3(F)COH
Molecular Weight:200.212
Hs Code.:2913000090
European Community (EC) Number:624-076-5
DSSTox Substance ID:DTXSID90374641
Wikidata:Q82163241
Mol file:57592-43-5.mol

Synonyms:57592-43-5;2-Fluorobiphenyl-4-carboxaldehyde;3-fluoro-4-phenylbenzaldehyde;2-Fluoro-[1,1'-biphenyl]-4-carbaldehyde;2-fluorobiphenyl-4-carbaldehyde;2-fluoro-biphenyl-4-carbaldehyde;SCHEMBL257774;DTXSID90374641;BBFKVFLWRKZSPM-UHFFFAOYSA-N;2-Fluoro-biphenyl-4-carboxaldehyde;MFCD05664220;AKOS015912957;2-Fluorobiphenyl-4-carboxaldehyde, 97%;AS-47774;CS-0269779;FT-0691683;F16102;EN300-1457898

Suppliers and Price of 2-Fluorobiphenyl-4-carboxaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
2-Fluorobiphenyl-4-carboxaldehyde 97%
5g
$ 187.00

Rieke Metals
3-Fluoro-4-phenylbenzaldehyde 97%
2g
$ 423.00

Rieke Metals
3-Fluoro-4-phenylbenzaldehyde 97%
1g
$ 251.00

Rieke Metals
3-Fluoro-4-phenylbenzaldehyde 97%
5g
$ 714.00

Matrix Scientific
3-Fluoro-4-phenylbenzaldehyde
5g
$ 636.00

Matrix Scientific
3-Fluoro-4-phenylbenzaldehyde
1g
$ 252.00

Matrix Scientific
3-Fluoro-4-phenylbenzaldehyde
2g
$ 401.00

Crysdot
2-Fluoro-[1,1'-biphenyl]-4-carbaldehyde 95+%
5g
$ 420.00

American Custom Chemicals Corporation
3-FLUORO-4-PHENYLBENZALDEHYDE 95.00%
10G
$ 2292.10

American Custom Chemicals Corporation
3-FLUORO-4-PHENYLBENZALDEHYDE 95.00%
1G
$ 278.25

Total 11 raw suppliers

Chemical Property of 2-Fluorobiphenyl-4-carboxaldehyde

Chemical Property:

Vapor Pressure:0.000428mmHg at 25°C
Melting Point:27-31 °C(lit.)
Refractive Index:1.59
Boiling Point:315.8°Cat760mmHg
Flash Point:207.2°C
PSA：17.07000
Density:1.173g/cm³
LogP:3.30520
Storage Temp.:2-8°C
XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:200.063743068
Heavy Atom Count:15
Complexity:211

Purity/Quality:

97% ^*data from raw suppliers

2-Fluorobiphenyl-4-carboxaldehyde 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=C(C=C(C=C2)C=O)F
Uses 2-Fluorobiphenyl-4-carboxaldehyde may be used as a starting material in the synthesis of (2-fluoro-1,1′-biphenyl-4-yl)acetic acid, a novel unsubstituted flurbiprofen (FLU) derivative.

Technology Process of 2-Fluorobiphenyl-4-carboxaldehyde

There total 5 articles about 2-Fluorobiphenyl-4-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 133059-43-5
4-bromo-3-fluorobenzaldehyde

: 98-80-6
phenylboronic acid

: 57592-43-5
2-fluoro-1,1'-biphenyl-4-carbaldehyde

Guidance literature:: With potassium phosphate tribasic trihydrate; 1-(tert-butyl)-2-(diphenylphosphaneyl)-1H-imidazole; palladium dichloride; In ethanol; at 60 ℃; for 1h; Inert atmosphere; Schlenk technique;
DOI:10.1002/jhet.3071

Reference yield: 70.0%

: 41604-19-7
1-bromo-3-fluoro-4-phenylbenzene

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 57592-43-5
2-fluoro-1,1'-biphenyl-4-carbaldehyde

Guidance literature:: 1-bromo-3-fluoro-4-phenylbenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/jacs.9b02776

Reference yield: 62.5%

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 57592-43-5
2-fluoro-1,1'-biphenyl-4-carbaldehyde

Guidance literature:: 1-bromo-3-fluoro-4-phenylbenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1.16667h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 - 20 ℃; for 5h;