4-Trifluoroacetamidoaniline

Base Information

Chemical Name:4-Trifluoroacetamidoaniline
CAS No.:53446-90-5
Molecular Formula:C8H7F3N2O
Molecular Weight:204.152
Hs Code.:2924299090
European Community (EC) Number:622-164-8
DSSTox Substance ID:DTXSID20350175
Wikidata:Q82125980
Mol file:53446-90-5.mol

Synonyms:4-trifluoroacetamidoaniline;p-trifluoroacetamidoaniline

Suppliers and Price of 4-Trifluoroacetamidoaniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Trifluoroacetamidoaniline
500mg
$ 135.00

Medical Isotopes, Inc.
4-Trifluoroacetamidoaniline
5 g
$ 1760.00

Crysdot
N-(4-Aminophenyl)-2,2,2-trifluoroacetamide 95+%
25g
$ 496.00

American Custom Chemicals Corporation
4-TRIFLUOROACETAMIDOANILINE 95.00%
5G
$ 2044.35

American Custom Chemicals Corporation
4-TRIFLUOROACETAMIDOANILINE 95.00%
500MG
$ 739.20

Alichem
N-(4-Aminophenyl)-2,2,2-trifluoroacetamide
25g
$ 516.03

AHH
4-Trifluoroacetamidoaniline 97%
5g
$ 475.00

Total 10 raw suppliers

Chemical Property of 4-Trifluoroacetamidoaniline

Chemical Property:

Vapor Pressure:0.126mmHg at 25°C
Melting Point:118 °C
Refractive Index:1.553
Boiling Point:218.4°C at 760 mmHg
Flash Point:85.9°C
PSA：55.12000
Density:1.445g/cm³
LogP:2.42380
Storage Temp.:−20°C
Solubility.:Diethyl Ether, Ethanol, Ethyl Acetate
XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:204.05104734
Heavy Atom Count:14
Complexity:209

Purity/Quality:

98%min ^*data from raw suppliers

4-Trifluoroacetamidoaniline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=CC(=CC=C1N)NC(=O)C(F)(F)F
Uses TFAN reacts with reducing oligosaccharides in the presence of sodium cyanoborohydride to give aminoalditol derivatives, useful for linking to proteins or solid matrices. Treated this way, reducing oligosaccharides were easily separated by HPLC. 4-Trifluoroacetyl-p-phenylenediaMine reacts with reducing oligosaccharides in the presence of sodium cyanoborohydride to give aminoalditol derivatives, useful for linking to proteins or solid matrices. Treated this way, reducing oligosaccharides were easily separated by HPLC

Technology Process of 4-Trifluoroacetamidoaniline

There total 3 articles about 4-Trifluoroacetamidoaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 404-27-3
2,2,2-trifluoro-N-(4-nitrophenyl)acetamide

: 53446-90-5
N-(4-Amino-phenyl)-2,2,2-trifluoro-acetamide

Guidance literature:: With hydrogenchloride; iron; In ethanol; water; for 3h; Reflux;
DOI:10.1039/C6RA24392D

Reference yield:

: 100-01-6,104810-17-5
4-nitro-aniline

: 53446-90-5
N-(4-Amino-phenyl)-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 18 h

2: iron; hydrogenchloride / ethanol; water / 3 h / Reflux

With pyridine; hydrogenchloride; iron; In ethanol; dichloromethane; water;
DOI:10.1039/C6RA24392D