404-27-3

Basic information

• Product Name: 2,2,2-Trifluoro-4'-nitroacetanilide
• Synonyms: 2,2,2-Trifluoro-4'-nitroacetanilide;2,2,2-Trifluoro-N-(4-nitrophenyl)acetaMide
• CAS NO: 404-27-3
• Molecular Formula: C₈H₅F₃N₂O₃
• Molecular Weight: 234.13
• Product Categories: Amines;Aromatics
• Mol File: 404-27-3.mol
• Article Data: 27

Chemical Properties

• Melting Point: 149-150°C
• Appearance: /
• CAS DataBase Reference: 2,2,2-Trifluoro-4'-nitroacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-Trifluoro-4'-nitroacetanilide(404-27-3)
• EPA Substance Registry System: 2,2,2-Trifluoro-4'-nitroacetanilide(404-27-3)

Safety Data

• Hazardous Substances Data: 404-27-3(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

N-(p-Nitrophenyl)-2,2,2-trifluoroacetamide (cas# 404-27-3) is a compound useful in organic synthesis.

Upstream product

• 62-53-3 aniline 
• 407-25-0 trifluoroacetic anhydride 
• 404-24-0 2,2,2-trifluoro-N-phenylacetamide 
• 1492828-74-6 methyl 2,2,2-trifluoro-N-(p-nitrophenyl)acetimidate 
• 145372-31-2 N-(4-nitrophenyl)-2,2,2-trifluoroacetimidoyl chloride 
• 1228956-92-0 C₁₄H₁₄N₄O₂ 
• 100-01-6 4-nitro-aniline 
• 76-05-1 trifluoroacetic acid 
• 636-98-6 p-nitrobenzene iodide 
• 354-38-1 2,2,2-trifluoroacetamide 
• 27691-52-7 S,S-dimethyl-N-(p-nitrophenyl)sulfilimine 
• 2923-18-4 sodium 2,2,2-trifluoroacetate 
• 100-28-7 4-Nitrophenyl isocyanate 
• 51599-76-9 N-trifluoroacetoxy succinimide 

Downstream Products

• 53446-90-5 N-(4-Amino-phenyl)-2,2,2-trifluoro-acetamide 
• 75-89-8 2,2,2-trifluoroethanol 
• 100-01-6 4-nitro-aniline 
• 1830-44-0 (2-amino-5-nitro-phenyl)-pyridin-2-yl-methanone 
• 79692-35-6 Hexadecanoic acid (4-diethylamino-1-methyl-butyl)-[4-(3-{4-[(4-diethylamino-1-methyl-butyl)-hexadecanoyl-amino]-phenyl}-ureido)-phenyl]-amide 
• 344747-21-3 Hexadecanoic acid (4-diethylamino-1-methyl-butyl)-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-amide 
• 79692-45-8 Hexadecanoic acid (4-amino-phenyl)-(4-diethylamino-1-methyl-butyl)-amide 
• 79692-50-5 N-[4-(4-Diethylamino-1-methyl-butylamino)-phenyl]-2,2,2-trifluoro-acetamide 
• 62-53-3 aniline 
• 76-05-1 trifluoroacetic acid 
• 100-15-2 N-methyl(p-nitroaniline) 
• 100-23-2 N,N-Dimethyl-4-nitroaniline 

Relevant articles and documents

The reaction of 4-substituted aryl isocyanates with NaBH4/trifluoroacetic acid (TFA)

Treatment of 4-substituted aryl isocyanates (cf. 2a-f) with NaBH4/TFA leads to the corresponding 4-substituted N,N-bis(2,2,2-trifluoroethyl)aniline derivatives (3a-d) in excellent yield except where an electron-withdrawing group is present (cf.

Carbon-Carbon Bond Formation of Trifluoroacetyl Amides with Grignard Reagents via C(O)-CF3 Bond Cleavage

The reaction of trifluoroacetyl amides with Grignard reagent for the substitution of CF3 group with various alkyl or aryl groups is described. A variety of aryl, quinolin-8-yl, and (hetero)alkyl functional groups as well as F, Cl, and Br atoms are well tolerated. These moisture-stable and easily available trifluoroacetyl amides can be conveniently obtained and used as new versatile precursors for isocyanates. The control experiments show that the reaction proceeds via an isocyanate intermediate and/or alkoxide/amide dual anionic intermediate.

The development of N-aryl trifluoroacetimidate-based benzyl and allyl protecting group reagents

An exploration of the role of para-substituents on the balance between stability and reactivity of N-phenyl trifluoroacetimidates prompted the discovery of new reagents for the addition of allyl and benzyl protecting groups, namely O-allyl and O-benzyl N-