6-Nitro-7-Chloro-4-HydroxyQuinazoline

Base Information

• Chemical Name: 6-Nitro-7-Chloro-4-HydroxyQuinazoline
• CAS No.: 53449-14-2
• Molecular Formula: C8H4ClN3O3
• Molecular Weight: 225.591
• Hs Code.: 2933990090
• Mol file: 53449-14-2.mol

Synonyms:6-Nitro-7-Chloro-4-HydroxyQuinazoline;7-CHLORO 6-NITRO QUINAZOLINE 4-OL;7-Chloro-6-nitro-4-hydroxyquinazoline;6-Nitro-7-chloro-3,4-dihydroquinazolin-4-one;7-Chloro-1,4-dihydro-6-nitro-4-oxoquinazoline;7-Chloro-6-nitroquinazolin-4(1H)-one;7-Chloro-6-nitro-4-quinazolinol;7-Chloro-6-nitro-3H-quinazolin-4-one

Chemical Property of 6-Nitro-7-Chloro-4-HydroxyQuinazoline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 314-319℃
• Refractive Index: 1.756
• Boiling Point: 457.671 °C at 760 mmHg
• PKA: -2.49±0.20(Predicted)
• Flash Point: 230.591 °C
• PSA: 91.83000
• Density: 1.706 g/cm³
• LogP: 2.42020
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: slightly sol. in Dimethylformamide

Purity/Quality:

99% ^*data from raw suppliers

7-Chloro-6-nitro-4-hydroxyquinazoline >98.0%(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

Useful:

Technology Process of 6-Nitro-7-Chloro-4-HydroxyQuinazoline

There total 11 articles about 6-Nitro-7-Chloro-4-HydroxyQuinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.6%

7-chloro-3,4-dihydroquinazolin-4-one (31374-18-2) → 7-chloro-6-nitro-4(3H)-quinazolinone (53449-14-2)

Guidance literature:

With sulfuric acid; nitric acid; at 50 - 90 ℃;

DOI:10.1007/s00044-012-0408-0

Reference yield: 92.0%

→ 7-Chloro-6-nitro-quinazolin-4-one (53449-14-2)

Guidance literature:

Reference yield: 90.0%

4-chloro-5-nitroanthranilic acid (100948-85-4) + trimethyl orthoformate (149-73-5) → 7-Chloro-6-nitro-quinazolin-4-one (53449-14-2)

Guidance literature:

With ammonium acetate; In methanol; at 120 ℃; for 4h;

upstream raw materials:

7-chloro-3,4-dihydroquinazolin-4-one

2-amino-4-chlorobenzamide

2-Amino-4-chlorobenzoic acid

4-chloro-2-nitro-benzoic acid

Downstream raw materials:

7-morpholin-4-yl-6-nitro-3H-quinazolin-4-one

6-nitro-7(methylamino)quinazolin-4(3H)-one

7-benzylamino-6-nitro-3H-quinazolin-4-one

2-hydroxy-4-amino-1-nitrobenzene