IMIDAZO[1,2-A]PYRIDIN-2-YLACETONITRILE

Base Information

• Chemical Name: IMIDAZO[1,2-A]PYRIDIN-2-YLACETONITRILE
• CAS No.: 57892-77-0
• Molecular Formula: C9H7N3
• Molecular Weight: 157.17
• Hs Code.: 2933990090
• Mol file: 57892-77-0.mol

Synonyms:imidazo[1,2-a]pyridin-2-yl-acetonitrile;2-(imidazo[1,2-a]pyridin-2-yl)acetonitrile;

Chemical Property of IMIDAZO[1,2-A]PYRIDIN-2-YLACETONITRILE

Chemical Property:

• Melting Point: 91-92 °C(Solv: isopropanol (67-63-0))
• Refractive Index: 1.641
• Boiling Point: °Cat760mmHg
• PKA: 5.88±0.50(Predicted)
• Flash Point: °C
• PSA: 41.09000
• Density: 1.18g/cm³
• LogP: 1.40038

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-{imidazo[1,2-a]pyridin-2-yl}acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of IMIDAZO[1,2-A]PYRIDIN-2-YLACETONITRILE

There total 6 articles about IMIDAZO[1,2-A]PYRIDIN-2-YLACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

potassium cyanide (151-50-8) + 2-(bromomethyl)-1H-imidazo[1,2-a]pyridinium bromide → 2-(imidazo[1,2-a]pyridin-2-yl)acetonitrile (57892-77-0)

Guidance literature:

2-(bromomethyl)-1H-imidazo[1,2-a]pyridinium bromide; With sodium hydrogencarbonate; In methanol; water; for 0.0833333h;

potassium cyanide; In methanol; water; for 6h; Further stages.;

DOI:10.1007/s11178-008-2012-9

Reference yield:

potassium cyanide + 2-chloromethylimidazo[1,2-a]pyridine (57892-76-9) → 2-(imidazo[1,2-a]pyridin-2-yl)acetonitrile (57892-77-0)

Guidance literature:

In water; for 2h; Reflux;

DOI:10.1016/j.molstruc.2016.08.085

Reference yield:

2-chloromethylimidazo[1,2-a]pyridine (57892-76-9) → 2-(imidazo[1,2-a]pyridin-2-yl)acetonitrile (57892-77-0)

Guidance literature:

With sodium cyanide; In ethanol; water;

upstream raw materials:

potassium cyanide

2-chloromethylimidazo[1,2-a]pyridine

2-aminopyridine

imidazo[1,2-a]pyridine

Downstream raw materials:

2-{3-[(E)-2-(4-methoxyphenyl)diazenyl]-imidazo[1,2-a]pyridin-2-yl}-2-[(Z)-2-(4-methoxyphenyl)hydrazono]acetonitrile

(2Z)-{3-[(E)-phenyldiazenyl]imidazo[1,2-a]-pyridin-2-yl}(phenylhydrazono)acetonitrile

2-(2-aminoethyl)imidazo<1,2-a>pyridine

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