57892-76-9

Basic information

• Product Name: 2-(CHLOROMETHYL)IMIDAZO[1,2-A]PYRIDINE
• Synonyms: BUTTPARK 7\05-93;ART-CHEM-BB B016117;2-(CHLOROMETHYL)IMIDAZO[1,2-A]PYRIDINE;AKOS BBS-00001806;AKOS B016117;Imidazo[1,2-a]pyridine, 2-(chloromethyl)- (9CI);2-Chloromethylimidazo[1,2-a]pyridine hydrochloride;2-(chloromethyl)imidazo[1,2-a]pyridine(SALTDATA: FREE)
• CAS NO: 57892-76-9
• Molecular Formula: C₈H₇ClN₂
• Molecular Weight: 166.61
• Product Categories: HALOMETYL
• Mol File: 57892-76-9.mol
• Article Data: 29

Chemical Properties

• Melting Point: 84-85 °C(Solv: carbon tetrachloride (56-23-5))
• Appearance: /
• Density: 1.29 g/cm³
• PKA: 6.31±0.50(Predicted)
• CAS DataBase Reference: 2-(CHLOROMETHYL)IMIDAZO[1,2-A]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(CHLOROMETHYL)IMIDAZO[1,2-A]PYRIDINE(57892-76-9)
• EPA Substance Registry System: 2-(CHLOROMETHYL)IMIDAZO[1,2-A]PYRIDINE(57892-76-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 57892-76-9(Hazardous Substances Data)

Usage

General Description

2-(Chloromethyl)imidazo[1,2-a]pyridine is a chemical compound that belongs to the family of heterocyclic compounds known as imidazo[1,2-a]pyridines. It consists of an imidazo[1,2-a]pyridine ring, which is a tricyclic compound featuring an imidazole ring fused to a pyridine ring, substituted with a (chloromethyl) group at the 2-position. This chemical does not have any notable commercial uses and is primarily utilized in the field of academic research. The properties of this chemical have yet to be thoroughly explored, but as a member of the imidazo[1,2-a]pyridine family, it may have potential implications in medicinal chemistry. Its detailed physical and chemical properties, such as solubility, melting point, and toxicity, might be determined through experimental procedures.

Upstream product

• 38922-77-9 ethyl 3-imidazo[1,2-a]pyridine-2-carboxylate 
• 82090-52-6 2-hydroxymethyl-imidazo[1,2-a]pyridine 
• 274-76-0 imidazo[1,2-a]pyridine 
• 534-07-6 1,3-Dichloroacetone 
• 504-29-0 2-aminopyridine 
• 144-55-8 sodium hydrogencarbonate 
• 109-12-6 2-aminopyrimidine 
• 20485-53-4 1-chloro-3-diazopropan-2-one 
• 53535-68-5 bromo-3-chloro-propanone 

Downstream Products

• 57892-77-0 2-(imidazo[1,2-a]pyridin-2-yl)acetonitrile 
• 1448754-44-6 4-(imidazo[1,2-a]pyridin-2-ylmethyl)-7-(4-(trifluoromethyl)phenyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one hydrochloride salt 
• 1454918-41-2 C₂₀H₁₆N₄O₂ 
• 43170-96-3 2-(2-aminoethyl)imidazo<1,2-a>pyridine 
• 1346569-79-6 ethyl 3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enoate 
• 1346569-76-3 3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enoic acid 
• 1346569-40-1 2-({4-[2-(4-chlorophenyl)-1-(5-methyl-4H-1,2,4-triazol-3-yl)ethenyl]phenoxy}methyl)imidazo[1,2-a]pyridine 
• 1346568-89-5 2-({4-[2-(4-chlorophenyl)-1-(1,3,4-oxadiazol-2-yl)vinyl]phenoxy}methyl)imidazo[1,2-a]pyridine 
• 1346567-72-3 3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]-N-methyl-prop-2-enamide 
• 1346570-36-2 3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enehydrazide 
• 120159-89-9 2-[[[3-bis(propylthio)-methyl]phenoxy]methyl]imidazo[1,2-a]pyridine hydrochloride 
• 135921-68-5 E-2-(2-phenyl cyclopentylidenemethyl) 3-nitroimidazo<1,2-a>pyridine 

Relevant articles and documents

Domino benzylic-amination-sonogashira-heterocyclisation reaction: Direct access to dipyrido[1,2-a:3',4'-d]imidazole salts

A new one-pot domino process, involving four chemical transformations, for the synthesis of new dipyrido[1,2-a:3',4'-d]imidazole salts in a multicomponent reaction is reported. Various dipyrido[1,2-a:3',4'-d]imidazoles were obtained in moderate to good yi

METTL3 INHIBITORY COMPOUNDS

The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X-Y-Z5 (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity 10 is implicated.

Synthesis and characterization of fused imidazole heterocyclic selenoesters and their application for chemical detoxification of HgCl2

A new series of selenoester derivatives of imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine was synthesized under mild conditions using a simple methodology by the reaction of in situ generated sodium selenocarboxylates with 2-(chloromethyl)imidazo[1,2