57892-76-9Relevant academic research and scientific papers
Domino benzylic-amination-sonogashira-heterocyclisation reaction: Direct access to dipyrido[1,2-a:3',4'-d]imidazole salts
Henry, Nicolas,Thiery, Emilie,Petrignet, Julien,Halouchi, Hassan,Thibonnet, Jerome,Abarbri, Mohamed
, p. 6212 - 6217,6 (2012)
A new one-pot domino process, involving four chemical transformations, for the synthesis of new dipyrido[1,2-a:3',4'-d]imidazole salts in a multicomponent reaction is reported. Various dipyrido[1,2-a:3',4'-d]imidazoles were obtained in moderate to good yi
Design, Synthesis, Anti-Cancer Activity, and in silico Studies of Novel Imidazo[1,2-a]pyridine Derivatives
Bodige, S.,Chandra, J. N. Narendra Sharath,Endoori, S.,Gulipalli, K. C.,Seelam, N.
, p. 1727 - 1736 (2020/10/15)
Abstract: A novel series of imidazo [1,2-a]pyridinederivatives has been designed, synthesized and tested for the anti-proliferativeactivity against three different human cancer cell lines. Most of thesynthesized compounds exhibit anti-proliferative activi
METTL3 INHIBITORY COMPOUNDS
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, (2020/10/20)
The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X-Y-Z5 (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity 10 is implicated.
INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF
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, (2019/09/30)
The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
Synthesis and characterization of fused imidazole heterocyclic selenoesters and their application for chemical detoxification of HgCl2
Sharma, Nidhi,Kumar, Sanjeev,Kumar, Sangit,Mehta,Bhasin
, p. 2702 - 2710 (2018/02/19)
A new series of selenoester derivatives of imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine was synthesized under mild conditions using a simple methodology by the reaction of in situ generated sodium selenocarboxylates with 2-(chloromethyl)imidazo[1,2
INDOLE AHR INHIBITORS AND USES THEREOF
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Paragraph 00270, (2018/11/22)
The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
REDUCTION OF PRO-INFLAMMATORY HDL USING A LEUKOTRIENE INHIBITOR
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Paragraph 00185; 00198, (2018/09/12)
A method involving the administration of a therapeutically effective amount of a leukotriene inhibitor, a pharmaceutically acceptable salt, a pharmaceutically acceptable N-oxide, a pharmaceutically active metabolite, a pharmaceutically acceptable prodrug, or pharmaceutically acceptable solvate thereof to a human for reducing a level of pro-inflammatory HDL in the human. Various examples of leukotriene inhibitors, including 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin- 3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2, 2-dimethyl-propionic acid, are disclosed for administration for the reduction of pro-inflammatory HDL in a human. Reduction of pro-inflammatory HDL by the leukotriene inhibitor may include conversion of at least a portion of pro-inflammatory HDL to anti-inflammatory HDL.
New fluorescent heterocyclic systems from imidazo[1,2-a]pyridine: Design, synthesis, spectral studies and quantum-chemical investigations
Pordel, Mehdi,Chegini, Hamed,Ramezani, Shirin,Daee, Mohammadreza
, p. 105 - 112 (2016/10/04)
Two new fluorescent heterocyclic systems dipyrido[1′,2′:1,2]imidazo[4,5-b:4,5-e]pyridine-13-carbonitrile and pyrido[1′,2′:1,2]imidazo[4,5-b]pyrido[2′,1′:2,3]imidazo[4,5-e]pyridine-13-carbonitrile were synthesized by one-pot reaction of imidazo[1,2-a]pyridine with 2-(imidazo[1,2-a]pyridin-3-yl)acetonitrile and 2-(imidazo[1,2-a]pyridin-2-yl)acetonitrile, respectively, in MeOH/KOH solution via the nucleophilic substitution of hydrogen in high yields. Spectral and analytical data have confirmed the structures of the synthesized dyes. The optical and solvatochromic properties of the compounds were investigated and the results showed that they exhibited interesting photophysical properties. Density functional theory (DFT) calculations of fluorescent dyes were performed to provide the optimized geometries and relevant frontier orbitals by using the B3LYP hybrid functional and the 6–311?++ G(d,p) basis set. Calculated electronic absorption spectra were also obtained by time-dependent density functional theory (TD-DFT) method. In addition, electron density iso-surface map, intra- and intermolecular interactions of these fluorescent heterocyclic systems were evaluated by AIM (Atoms in Molecules) analysis.
COMPOUNDS FOR TREATING RESPIRATORY SYNCYTIAL VIRUS INFECTIONS
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Page/Page column 35, (2016/09/15)
The present disclosure provides compounds useful in the treatment of viral infections, in particular respiratory syncytial viral (RSV) infections. In one aspect of the invention, there is provided compounds of the formula (I): These an additional compound
IMIDAZOPYRIDINE DERIVATIVES USEFUL IN TREATING DIABETES
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Paragraph 0121; 0122, (2015/07/15)
The present invention relates to imidazopyridine derivatives of the following general formula I: and to their use as a drug, in particular in treating and/or preventing diabetes, its complications and/or associated pathologies.
