2-(1H-INDOL-3-YL)-2-OXO-ETHYLAMINE HCL

Base Information

• Chemical Name: 2-(1H-INDOL-3-YL)-2-OXO-ETHYLAMINE HCL
• CAS No.: 53552-11-7
• Molecular Formula: C10H11ClN2O
• Molecular Weight: 210.66
• Hs Code.: 2933990090
• Mol file: 53552-11-7.mol

Synonyms:2-AMINO-1-(1H-INDOL-3-YL)-ETHANONE HYDROCHLORIDE;2-(1H-INDOL-3-YL)-2-OXO-ETHYLAMINE HCL;2-(1H-Indol-3-yl)-2-oxo-ethylamine hydrochloride

Chemical Property of 2-(1H-INDOL-3-YL)-2-OXO-ETHYLAMINE HCL

Chemical Property:

• PSA: 58.88000
• LogP: 2.81160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-amino-1-(1H-indol-3-yl)ethanoneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(1H-INDOL-3-YL)-2-OXO-ETHYLAMINE HCL

There total 11 articles about 2-(1H-INDOL-3-YL)-2-OXO-ETHYLAMINE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-bromo-1-(1H-indol-3-yl)ethanone (19611-93-9) → <2-(1H-indol-3-yl)-2-oxoethyl> ammonium chloride (53552-11-7)

Guidance literature:

With hexamethylenetetramine; In chloroform; acetone; for 3h; Ambient temperature;

DOI:10.1002/hlca.19940770726

Reference yield: 92.0%

2-azido-1-(1H-indol-3-yl)ethan-1-one (17380-40-4) → <2-(1H-indol-3-yl)-2-oxoethyl> ammonium chloride (53552-11-7)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; for 3h;

DOI:10.1055/s-2006-950318

Reference yield: 89.0%

N-[2-oxo-2-(3-indolyl)ethyl]carbamic acid tert-butyl ester (689232-04-0) → <2-(1H-indol-3-yl)-2-oxoethyl> ammonium chloride (53552-11-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.tet.2010.03.012

upstream raw materials:

2-bromo-1-(1H-indol-3-yl)ethanone

2-azido-1-(1H-indol-3-yl)ethan-1-one

3-acetylindole

indole

Downstream raw materials:

prealmazole C

(S)-2-(1-benzyloxycarbonylamino-2-methylpropyl)-5-(indol-3-yl)-N-[2-(indol-3-yl)-2-oxo-ethyl]oxazole-4-carbamide

grossularine-1

almazole C

Refernces

• 1、 Kim, Ahhyun,Kim, Min Jeong,Noh, Tae Hwan,Hong, Jongki,Liu, Yonghong,Wei, Xiaoyi,Jung, Jee H.. "Synthesis and antibacterial evaluation of hamacanthin B analogues". . p. 5013 - 5017. Retrieved 2016.
• 2、 Sperry, Jonathan,Moody, Christopher J.. "Diazonamide studies. A direct synthesis of the indole bis-oxazole fragment from tri- and tetra-peptides using biomimetic oxidative cyclizations". experimental part. p. 6483 - 6495. Retrieved 2010/10/19.