(s)-2-Amino-3-benzyloxy-1-propanol

Base Information

• Chemical Name: (s)-2-Amino-3-benzyloxy-1-propanol
• CAS No.: 58577-88-1
• Molecular Formula: C10H15NO2
• Molecular Weight: 181.235
• Hs Code.: 2922500090
• European Community (EC) Number: 679-208-4
• DSSTox Substance ID: DTXSID001270357
• Nikkaji Number: J1.419.957H
• Mol file: 58577-88-1.mol

Synonyms:58577-88-1;(s)-2-amino-3-benzyloxy-1-propanol;H-D-Ser(Bzl)-ol;(S)-2-Amino-3-(benzyloxy)propan-1-ol;(S)-(-)-2-Amino-3-benzyloxy-1-propanol;(2S)-2-amino-3-phenylmethoxypropan-1-ol;1-Propanol, 2-amino-3-(phenylmethoxy)-, (2S)-;(2S)-2-Amino-3-(benzyloxy)propan-1-ol;MFCD04112477;SCHEMBL2031567;ZJUOMDNENVWMPL-JTQLQIEISA-N;DTXSID001270357;AKOS006282491;AS-46930;CS-0089909;(2S)-2-Amino-3-(phenylmethoxy)-1-propanol;EN300-92996;F10947;(S)-(-)-2-Amino-3-benzyloxy-1-propanol, 97%

Chemical Property of (s)-2-Amino-3-benzyloxy-1-propanol

Chemical Property:

• Boiling Point: 340.0±27.0 °C(Predicted)
• PKA: 12.53±0.10(Predicted)
• PSA: 55.48000
• Density: 1 +-.0.06 g/cm3(Predicted)
• LogP: 1.22310
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 181.110278721
• Heavy Atom Count: 13
• Complexity: 124

Purity/Quality:

97% ^*data from raw suppliers

(S)-(-)-2-Amino-3-benzyloxy-1-propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COCC(CO)N
• Isomeric SMILES: C1=CC=C(C=C1)COC[C@H](CO)N
• Uses: (S)-(-)-2-Amino-3-benzyloxy-1-propanol is used as an organic chemical synthesis intermediate.

Technology Process of (s)-2-Amino-3-benzyloxy-1-propanol

There total 6 articles about (s)-2-Amino-3-benzyloxy-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(2R)-3-benzyloxy-2-aminopropanoic acid methyl ester (84907-81-3) → (2S)-2-amino-3-(benzyloxy)propan-1-ol (58577-88-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2009.09.019

Reference yield: 69.0%

O-benzyl-D-serine (10433-52-0,32520-12-0) → (2S)-2-amino-3-(benzyloxy)propan-1-ol (58577-88-1)

Guidance literature:

O-benzyl-D-serine; With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Reflux;

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 18h;

DOI:10.1016/j.bmc.2012.08.007

Reference yield:

(R)-4-Benzyloxymethyl-2-phenyl-4,5-dihydro-oxazole (287107-19-1) → (2S)-2-amino-3-(benzyloxy)propan-1-ol (58577-88-1)

Guidance literature:

(R)-4-Benzyloxymethyl-2-phenyl-4,5-dihydro-oxazole; With hydrogenchloride; In water;

With sodium hydroxide; In water;

upstream raw materials:

O-benzyl-D-serine

L-serine benzyl ester

N-acetyl-O-benzyl-D-serine

Methyl-N-acetyl-O-benzyl-D-serinat

Downstream raw materials:

C₂₄H₄₁NO₃

(2R)-3-(benzyloxy)-2-({(2R)-2-[6-(2,5-dimethyl-1H-pyrrol-1-yl)pyridin-3-yl]-2-hydroxyethyl}amino)propan-1-ol

(5R)-5-[(benzyloxy)methyl]-[1,3,4]-oxathiazinane-3,3-dioxide

(1S)-N-[(2-benzyloxy)-1-(hydroxymethyl)ethyl]chloromethane sulphonamide