N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide

Base Information

Chemical Name:N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
CAS No.:54192-66-4
Molecular Formula:C22H25NO6
Molecular Weight:399.44
Hs Code.:
DSSTox Substance ID:DTXSID20274387,DTXSID80859058
Nikkaji Number:J3.375.337C
Wikidata:Q26998324
Pharos Ligand ID:H8JS1GYU614K
Metabolomics Workbench ID:143523
ChEMBL ID:CHEMBL87
Mol file:54192-66-4.mol

Synonyms:(R/S)-Colchicine;Colchine;209810-38-8;(+/-)-Colchicine;54192-66-4;N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide;(+-)-COLCHICINE;CHEBI:23359;N-(1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide;Acetamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-;(S)-Colchicine >95%;Acetamide, N-(5,6,7,9-tetrahydro-1,2, 3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-;(S)-(-)-colchicine;CHEMBL87;Epitope ID:141498;Neuro_000002;MLS001181527;SCHEMBL675246;DTXSID20274387;DTXSID80859058;HMS2875H17;HMS3267B14;HMS3414L21;HMS3678L19;Acetamida, n-[(7s)-5,6,7,9-tetrahidro-1,2,3,10-tetrametoxi-9-oxobenzo [a] heptalen-7-il]-;BCP09065;AC-281;BBL010108;CCG-46868;STK801462;AKOS003381878;AKOS016374434;AT27317;DB01394;( inverted exclamation markA)-Colchicine;NCGC00094629-01;NCGC00094629-02;NCGC00094629-03;NCGC00094629-04;NCGC00094629-05;NCGC00094629-06;NCGC00094629-08;AS-14691;SMR000567246;CS-0254169;FT-0665155;FT-0665156;EN300-111127;AB00830494-06;Q326224;J-013744;SR-01000636539-1;BRD-A46684810-001-04-6;Z1431321925;1,2,3,10-Tetramethoxy-7-(acetylamino)-5,6,7,9-tetrahydrobenzo[a]heptalene-9-one;Benzo[a]heptalen-9(5H)-one,7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-;N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide #;N-{3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0,2,7]hexadeca-1(16),2,4,6,11,14-hexaen-10-yl}acetamide

Suppliers and Price of N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide

Chemical Property:

PSA：83.09000
LogP:3.26250
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:399.16818752
Heavy Atom Count:29
Complexity:740

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

Technology Process of N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide

There total 118 articles about N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 108-24-7
acetic anhydride

: 186374-95-8
(S)-tert-butyl N-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalene-7-yl)carbamate

: 64-86-8,54192-66-4
colchicine

Guidance literature:: (S)-tert-butyl N-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalene-7-yl)carbamate; With hydrogenchloride; In diethyl ether; at 20 ℃; for 1h;

acetic anhydride; With dmap; triethylamine; In diethyl ether; at 25 ℃; for 10h;
DOI:10.1016/S0040-4020(00)00862-0

Reference yield: 85.0%

: methoxymagnesium bromide

: 10-demethoxy-10-tosylcolchicine

: 64-86-8,54192-66-4
colchicine

Guidance literature:: In tetrahydrofuran; for 5h;
DOI:10.1021/jm00058a013

Reference yield: 81.0%

: C₂₂H₂₇NO₇

: 64-86-8,54192-66-4
colchicine

Guidance literature:: With N,N-dimethyl-ethanamine; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/acs.orglett.7b02224