(+)-Colchicine

Base Information

Chemical Name:(+)-Colchicine
CAS No.:75520-89-7
Molecular Formula:C₂₂H₂₅NO₆
Molecular Weight:399.444
Hs Code.:
Mol file:75520-89-7.mol

Synonyms:Benzo[a]heptalene,acetamide deriv.; (+)-Colchicine

Suppliers and Price of (+)-Colchicine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(R)-COLCHICINE 95.00%
5MG
$ 495.35

Biosynth Carbosynth
(+)-Colchicine
1 mg
$ 500.00

Biosynth Carbosynth
(+)-Colchicine
2 mg
$ 900.00

Biosynth Carbosynth
(+)-Colchicine
5 mg
$ 1800.00

Biosynth Carbosynth
(+)-Colchicine
10 mg
$ 2800.00

Biosynth Carbosynth
(+)-Colchicine
25 mg
$ 5000.00

TRC
(R)-Colchicine
2.5mg
$ 545.00

Total 10 raw suppliers

Chemical Property of (+)-Colchicine

Chemical Property:

Vapor Pressure:6.21E-21mmHg at 25°C
Melting Point:106-132°C
Boiling Point:726°C at 760 mmHg
Flash Point:392.9°C
PSA：83.09000
Density:1.25g/cm³
LogP:3.26250
Storage Temp.:-20?C Freezer

Purity/Quality:

99% ^*data from raw suppliers

(R)-COLCHICINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses The R-enantiomer of Colchicine (C640000). An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Technology Process of (+)-Colchicine

There total 27 articles about (+)-Colchicine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 108-24-7
acetic anhydride

: 102419-91-0
(+)-N-deacetylcolchicine

: 75520-89-7,54192-66-4
(+)-colchicine

Guidance literature:: With sodium hydrogencarbonate; In chloroform; water; for 2.5h;
DOI:10.1021/jo00363a021

Reference yield:

: 73307-44-5,68296-64-0
7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one

: 75520-89-7,54192-66-4
(+)-colchicine

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / Na₂CO₃ / diethyl ether / 2.5 h / Ambient temperature

2: 46 percent / methanol; diethyl ether / 3 h

3: 70 percent / K₂CO₃ / acetone; H₂O / 60 °C

5: 80 percent / NaHCO₃ / CHCl₃; H₂O / 2.5 h

With sodium hydrogencarbonate; sodium carbonate; potassium carbonate; In methanol; diethyl ether; chloroform; water; acetone;
DOI:10.1021/jo00363a021

Reference yield:

: 3482-37-9,73307-44-5
(+)-N-deacetylcolchiceine

: 75520-89-7,54192-66-4
(+)-colchicine

Guidance literature:: Multi-step reaction with 2 steps

1: benzene / 1 h / 50 - 60 °C

2: diethyl ether

In diethyl ether; benzene;
DOI:10.1021/jm00135a005