5-Methyl-3(2H)-benzofuranone

Base Information

• Chemical Name: 5-Methyl-3(2H)-benzofuranone
• CAS No.: 54120-66-0
• Molecular Formula: C9H8O2
• Molecular Weight: 148.161
• Hs Code.: 2932999099
• Mol file: 54120-66-0.mol

Synonyms:5-Methyl-3(2H)-benzofuranone;5-METHYLBENZOFURAN-3-ONE

Chemical Property of 5-Methyl-3(2H)-benzofuranone

Chemical Property:

• Melting Point: 54 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 283.3±40.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.211±0.06 g/cm3(Predicted)
• LogP: 1.57010

Purity/Quality:

98% ^*data from raw suppliers

5-methyl-2,3-dihydro-1-benzofuran-3-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Methyl-3(2H)-benzofuranone

There total 14 articles about 5-Methyl-3(2H)-benzofuranone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-ethynyl-1-methoxy-4-methylbenzene (104971-07-5) → 5-methyl-benzofuran-3-one (54120-66-0)

Guidance literature:

With methanesulfonic acid; 8-isopropyl-quinoline-N-oxide; (2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)Au(1H-benzotriazole)NTf₂; In 1,2-dichloro-ethane; at 20 ℃; for 5h;

DOI:10.1002/asia.201403032

Reference yield: 91.0%

2-ethynyl-4-methylphenol (183589-14-2) → 5-methyl-benzofuran-3-one (54120-66-0)

Guidance literature:

With pyridine N-oxide; mercuric triflate; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 30.0%

2-chloroacetic acid 4-methylphenyl ester (15150-39-7) → 5-methyl-benzofuran-3-one (54120-66-0)

Guidance literature:

With aluminum (III) chloride; at 140 ℃; for 2h;

upstream raw materials:

2-chloroacetyl-4-methylphenol

2-(4-methylphenoxy)acetyl chloride

2-(4-methylphenoxy)acetic acid

2‐bromo‐1‐(2‐hydroxy‐5‐methylphenyl)ethanone

Downstream raw materials:

(Z)-5-methyl-2-(3-nitrobenzylidene)benzofuran-3(2H)-one

C₁₇H₁₄O₂

5-methylbenzofuran-3-carbaldehyde

2-(5-methylbenzofuran-3-yl)acetic acid

Refernces

• 1、 -. "Catalytic synthesis method of 3-benzofuranone compound". Paragraph 0018; 0019. . Retrieved 2020/05/14.
• 2、 Wang, Sheng,Xu, Lei,Lu, Yu-Ting,Liu, Yu-Fei,Han, Bing,Liu, Ting,Tang, Jie,Li, Jia,Wu, Jiangping,Li, Jing-Ya,Yu, Li-Fang,Yang, Fan. "Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet β-cells from apoptosis". . p. 195 - 208. Retrieved 2017/03/02.