6-Chloro-5-methylpyridin-3-ol

Base Information

• Chemical Name: 6-Chloro-5-methylpyridin-3-ol
• CAS No.: 54232-03-0
• Molecular Formula: C6H6BrNO
• Molecular Weight: 143.573
• Hs Code.: 2933399090
• European Community (EC) Number: 869-793-6
• ChEMBL ID: CHEMBL3236919
• DSSTox Substance ID: DTXSID30511472
• Wikidata: Q82370264
• Mol file: 54232-03-0.mol

Synonyms:6-Chloro-5-methylpyridin-3-ol;54232-03-0;2-Chloro-5-hydroxy-3-methylpyridine;6-Chloro-5-methyl-pyridin-3-ol;2-CHLORO-5-HYDROXY-3-METHYLPYRDINE;MFCD11519295;3-Pyridinol, 6-chloro-5-methyl-;SCHEMBL1765148;CHEMBL3236919;6-chloro-5-methylpyridine-3-ol;AMY8027;DTXSID30511472;UGDSWVXJJFIVAH-UHFFFAOYSA-N;AKOS006326006;CS-W003790;DS-1932;PB31577;6-CHLORO-5-METHYL-3-PYRIDINOL;AC-33328;SY024020;2-CHLORO-3-METHYL-5-HYDROXYPYRIDINE;FT-0647169;EN300-316792;A830054;J-508841;6-bromo-5-methyl-pyridin-3-ol

Chemical Property of 6-Chloro-5-methylpyridin-3-ol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.572
• Boiling Point: 352.96 °C at 760 mmHg
• PKA: 8.81±0.10(Predicted)
• Flash Point: 167.264 °C
• PSA: 33.12000
• Density: 1.313 g/cm³
• LogP: 1.74900
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 143.0137915
• Heavy Atom Count: 9
• Complexity: 99.1

Purity/Quality:

98% ^*data from raw suppliers

6-Chloro-5-methylpyridin-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CN=C1Cl)O

Technology Process of 6-Chloro-5-methylpyridin-3-ol

There total 8 articles about 6-Chloro-5-methylpyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(6-chloro-5-methylpyridin-3-yl)boronic acid (1003043-40-0) → 2-chloro-5-hydroxy-3-methylpyridine (54232-03-0)

Guidance literature:

With dihydrogen peroxide; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jm401808n

Reference yield: 89.0%

2-chloro-3-methyl-5-nitropyridine (22280-56-4) → 2-chloro-5-hydroxy-3-methylpyridine (54232-03-0) + 6-chloro-5-methylpyridin-3-amine (38186-82-2)

Guidance literature:

With acetic acid;

Reference yield: 89.0%

6-chloro-5-methylpyridine-3-yl acetate (54232-04-1) → 2-chloro-5-hydroxy-3-methylpyridine (54232-03-0)

Guidance literature:

With methanol; potassium carbonate; at 20 ℃; for 1h;

upstream raw materials:

6-chloro-5-methylpyridin-3-amine

(6-chloro-5-methylpyridin-3-yl)boronic acid

6-chloro-5-methylpyridine-3-yl acetate

2-chloro-3-methyl-5-nitropyridine

Downstream raw materials:

5-benzyloxy-2-chloro-3-methylpyridine

2-chloro-5-methoxy-3-methylpyridine

2-chloro-3-cyano-5-methoxypyridine

2-chloro-5-methoxy-3-pyridinecarboxylic acid