3-Methyl-5,6,7,8-tetrahydro-1,6-naphthyridine

Base Information

Chemical Name:3-Methyl-5,6,7,8-tetrahydro-1,6-naphthyridine
CAS No.:624734-27-6
Molecular Formula:C9H12N2
Molecular Weight:202.179
Hs Code.:
DSSTox Substance ID:DTXSID40493896
Wikidata:Q72512950
Mol file:624734-27-6.mol

Synonyms:3-METHYL-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE;83100-02-1;3-Methyl-5,6,7,8-tetrahydro-[1,6]naphthyridine;3-Methyl-5,6,7,8-tetrahyrdo-1,6-napthyridine;SCHEMBL4407148;DTXSID40493896;AKOS006331051;AB50085;CS-0456049;EN300-1645876

Suppliers and Price of 3-Methyl-5,6,7,8-tetrahydro-1,6-naphthyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine 97%
250 mg
$ 593.00

SynQuest Laboratories
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine 97%
1 g
$ 1595.00

Labseeker
3-methyl-5,6,7,8-tetrahydro-[1,6]naphthyridine 95
10g
$ 4200.00

Crysdot
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine 95+%
1g
$ 680.00

Abosyn
3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine 95%-98%
1g
$ 399.00

Total 15 raw suppliers

Chemical Property of 3-Methyl-5,6,7,8-tetrahydro-1,6-naphthyridine

Chemical Property:

Vapor Pressure:0.0393mmHg at 25°C
Refractive Index:1.475
Boiling Point:266.2 °C at 760 mmHg
Flash Point:114.8 °C
PSA：24.92000
Density:1.045 g/cm³
LogP:1.36450
XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:148.100048391
Heavy Atom Count:11
Complexity:136

Purity/Quality:

97% ^*data from raw suppliers

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=C(CCNC2)N=C1
Uses 5,?6,?7,?8-?Tetrahydro-?3-?(trifluoromethyl)?-1,?6-?naphthyridine could be a useful aryl aminopyridine phosphodiesterase 10 inhibitor for treating central nervous system disorders.

Technology Process of 3-Methyl-5,6,7,8-tetrahydro-1,6-naphthyridine

There total 11 articles about 3-Methyl-5,6,7,8-tetrahydro-1,6-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 624734-26-5
tert-butyl 3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

: 624734-27-6
3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

Guidance literature:: With hydrogenchloride; water; In 1,3-dioxane; at 20 ℃; for 2h;

Reference yield:

: 3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine di-trifluoroacetic salt

: 624734-27-6
3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

Guidance literature:: 3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine di-trifluoroacetic salt; With sodium hydroxide; In water;

With di-tert-butyl dicarbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; at 20 ℃;

With hydrogenchloride; sodium hydrogencarbonate; more than 3 stages;

Reference yield:

: 2-hydroxy-5-(trifluoromethyl)nicotinonitrile

: 624734-27-6
3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: quinoline; trichlorophosphate / 3 h / Heating / reflux

2.1: sodium hydride / tetrahydrofuran / 20 °C

3.1: hydrogen / Raney Ni / ethanol / 2068.65 Torr

4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5.1: borane-THF / tetrahydrofuran / 20 °C

5.2: 50 °C

5.3: 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With quinoline; hydrogenchloride; borane-THF; hydrogen; sodium hydride; trifluoroacetic acid; trichlorophosphate; Raney Ni; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;