tert-butyl 3-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate

Base Information

Chemical Name:tert-butyl 3-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate
CAS No.:624734-26-5
Molecular Formula:C14H17F3N2O2
Molecular Weight:302.29
Hs Code.:
Mol file:624734-26-5.mol

Synonyms:tert-Butyl 3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate;

Suppliers and Price of tert-butyl 3-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Acrotein
tert-Butyl3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate 97%
1g
$ 467.08

Total 12 raw suppliers

Chemical Property of tert-butyl 3-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate

Chemical Property:

Boiling Point:342.4±42.0 °C at 760 mmHg
PKA:2.89±0.20(Predicted)
Flash Point:160.9±27.9 °C
PSA：42.43000
Density:1.3±0.1 g/cm³
LogP:3.33150

Purity/Quality:

NLT 98% ^*data from raw suppliers

tert-Butyl3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl 3-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate

There total 16 articles about tert-butyl 3-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: (Z)-N-(3-(dimethylamino)-2-(trifluoromethyl)allyllyl)-N-methylmethylamine quaternary ammonium hexafluorophosphate

: 624734-26-5
tert-butyl 3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

Guidance literature:: N-tert-butyloxycarbonylpiperidin-4-one; (Z)-N-(3-(dimethylamino)-2-(trifluoromethyl)allyllyl)-N-methylmethylamine quaternary ammonium hexafluorophosphate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -24 - 20 ℃; for 3.25h;

With ammonium acetate; acetic acid; In tetrahydrofuran; at -20 - 64 ℃; for 3.3h;

Reference yield: 60.8%

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: (Z)-N-(3-(dimethylamino)-2-(trifluoromethyl)allylidene)-N-methylmethanaminium

: 624734-26-5
tert-butyl 3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; acetic acid; at -24 - 20 ℃; for 4.5h; Inert atmosphere;

Reference yield: 51.0%

: N-(3-(dimethylamino)-2-(trifluoromethyl)allylidene)-N-methylmethanaminium hexafluorophosphate(V)

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 624734-26-5
tert-butyl 3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

Guidance literature:: N-tert-butyloxycarbonylpiperidin-4-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 0.75h;

N-(3-(dimethylamino)-2-(trifluoromethyl)allylidene)-N-methylmethanaminium hexafluorophosphate(V); In tetrahydrofuran; at -20 ℃; for 2h;

With ammonium acetate; acetic acid; In tetrahydrofuran; at 65 ℃; for 2.5h;