METHYL 2-PHENYLETHYL SULFIDE

Base Information

• Chemical Name: METHYL 2-PHENYLETHYL SULFIDE
• CAS No.: 5925-63-3
• Molecular Formula: C9H12S
• Molecular Weight: 152.26
• Mol file: 5925-63-3.mol

Synonyms:METHYL 2-PHENYLETHYL SULFIDE

Chemical Property of METHYL 2-PHENYLETHYL SULFIDE

Chemical Property:

• PSA: 25.30000
• LogP: 2.59210

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-PHENYLETHYL SULFIDE

There total 19 articles about METHYL 2-PHENYLETHYL SULFIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + methylthiol (74-93-1) → methyl(phenethyl)sulfane (5925-63-3)

Guidance literature:

With C₃₈H₂₈Au₂F₁₂FeN₂O₈P₂S₄; In 1,4-dioxane; at 45 ℃; for 20h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1002/anie.201809051

Reference yield: 89.0%

phenethylmagnesium chloride (90878-19-6) + S-methyl thiosulfate O-sodium salt (42254-80-8) → methyl(phenethyl)sulfane (5925-63-3)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere; Green chemistry;

DOI:10.1021/ol500067f

Reference yield: 75.0%

(2-(methylsulfinyl)ethyl)benzene (7714-32-1) → methyl(phenethyl)sulfane (5925-63-3) + azidomethyl (phenethyl)sulfide

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; bis(p-nitrophenyl) azidophosphonate; In toluene; at 110 ℃; for 2h;

DOI:10.1016/j.tetlet.2017.08.065

upstream raw materials:

O,O-diethyl S-(2-phenyl)ethyl phosphorodithioate

1-phenyl-2-bromoethane

sodium thiomethoxide

methylthiol

Downstream raw materials:

1-[4-(2-methylsulfanyl-ethyl)-phenyl]-ethanone

[(p-cymene)RuCl₂(PhC₂H₄SMe)]

styrene

hexylbenzene

Refernces

• 1、 Nosek, Vladimír,Mí?ek, Ji?í. "Chemoenzymatic Deracemization of Chiral Sulfoxides". supporting information. p. 9849 - 9852. Retrieved 2018/07/31.
• 2、 Ishihara, Kotaro,Shioiri, Takayuki,Matsugi, Masato. "Pummerer rearrangement using bis(p-nitrophenyl) phosphorazidate as an azidation reagent: A novel synthesis of azidomethyl sulfides". supporting information. p. 3932 - 3935. Retrieved 2017/09/20.