2-PROPENOIC ACID, 3-(5-BROMO-3-THIENYL)-, ETHYL ESTER

Base Information

Chemical Name:2-PROPENOIC ACID, 3-(5-BROMO-3-THIENYL)-, ETHYL ESTER
CAS No.:58963-72-7
Molecular Formula:C9H9BrO2S
Molecular Weight:261.14
Hs Code.:
Mol file:58963-72-7.mol

Synonyms:2-PROPENOIC ACID, 3-(5-BROMO-3-THIENYL)-, ETHYL ESTER

Suppliers and Price of 2-PROPENOIC ACID, 3-(5-BROMO-3-THIENYL)-, ETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ETHYL-3-(5-BROMO-3-THIENYL)ACRYLATE 98.00%
25G
$ 1339.80

American Custom Chemicals Corporation
ETHYL-3-(5-BROMO-3-THIENYL)ACRYLATE 98.00%
5G
$ 825.83

Total 2 raw suppliers

Chemical Property of 2-PROPENOIC ACID, 3-(5-BROMO-3-THIENYL)-, ETHYL ESTER

Chemical Property:

PSA：54.54000
LogP:3.08690

Purity/Quality:

99% ^*data from raw suppliers

ETHYL-3-(5-BROMO-3-THIENYL)ACRYLATE 98.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-PROPENOIC ACID, 3-(5-BROMO-3-THIENYL)-, ETHYL ESTER

There total 1 articles about 2-PROPENOIC ACID, 3-(5-BROMO-3-THIENYL)-, ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 18791-79-2
5-bromo-3-thiophenecarbaldehyde

: 58963-72-7
ethyl (E)-3-(5-bromothiophen-3-yl)acrylate

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; 5-bromo-3-thiophenecarbaldehyde; With lithium chloride; In acetonitrile; at 0 ℃; for 0.166667h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃;

Reference yield:

: 58963-72-7
ethyl (E)-3-(5-bromothiophen-3-yl)acrylate

: 4-(trans-2-((cyclopropylmethyl)amino)cyclopropyl)-N-(4,4-difluorocyclohexyl)thiophene-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; water; ethanol / 0 - 20 °C

3.1: triethylamine; diphenylphosphoranyl azide / 20 - 80 °C

4.1: triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 8 h / 90 °C / 2280.15 Torr

5.1: sodium hydroxide / tetrahydrofuran; methanol; water / 0 - 20 °C

6.1: triethylamine; HATU / N,N-dimethyl-formamide

7.1: hydrogenchloride / ethyl acetate / 0 - 20 °C

8.1: sodium hydrogencarbonate / tetrahydrofuran; methanol / 2 h / 20 - 60 °C / Inert atmosphere

9.1: sodium tetrahydroborate / 1 h / 0 - 20 °C

9.2: 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; diphenylphosphoranyl azide; sodium hydride; sodium hydrogencarbonate; triethylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 58963-72-7
ethyl (E)-3-(5-bromothiophen-3-yl)acrylate

: N-(4,4-difluorocyclohexyl)-4-(trans-2-(tetrahydro-2H-pyran-4-ylamino)cyclopropyl)thiophene-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; water; ethanol / 0 - 20 °C

3.1: triethylamine; diphenylphosphoranyl azide / 20 - 80 °C

4.1: triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 8 h / 90 °C / 2280.15 Torr

5.1: sodium hydroxide / tetrahydrofuran; methanol; water / 0 - 20 °C

6.1: triethylamine; HATU / N,N-dimethyl-formamide

7.1: hydrogenchloride / ethyl acetate / 0 - 20 °C

8.1: sodium hydrogencarbonate / tetrahydrofuran; methanol / 2 h / 20 - 60 °C / Inert atmosphere

9.1: sodium tetrahydroborate / 1 h / 0 - 20 °C

9.2: 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; diphenylphosphoranyl azide; sodium hydride; sodium hydrogencarbonate; triethylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; mineral oil;