18791-79-2

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Bromothiophen-4-aldehyde is used as a key intermediate in the synthesis of various pharmaceuticals. Its reactive nature allows for the creation of new drug molecules with potential therapeutic applications.
Used in Agrochemical Production:
2-BROMOTHIOPHEN-4-ALDEHYDE is also utilized in the production of agrochemicals, contributing to the development of new pesticides and other agricultural products designed to improve crop yields and protect plants from pests.
Used in Dye Manufacturing:
2-Bromothiophen-4-aldehyde serves as a crucial component in the manufacturing of dyes, where its aromatic properties contribute to the color and stability of the final product.
Used in Fragrance and Flavor Industry:
Due to its distinct odor, 2-Bromothiophen-4-aldehyde is used as a raw material in the production of various fragrances and flavors, enhancing the sensory experience of consumer products.
Used in Material Science:
2-Bromothiophen-4-aldehyde has potential applications in the development of novel materials, where its unique chemical properties can be harnessed to create innovative products with specific characteristics.
Used as a Reagent in Organic Chemistry:
2-BROMOTHIOPHEN-4-ALDEHYDE is employed as a reagent in various organic chemistry reactions, facilitating the synthesis of complex organic molecules and contributing to advancements in chemical research.

InChI:InChI=1/C5H3BrOS/c6-5-1-4(2-7)3-8-5/h1-3H

Upstream product

• 1193-69-7 2,5-dibromo thiophene-3-carboxaldehyde 
• 498-62-4 3-thiophene carboxaldehyde 

Downstream Products

• 59786-36-6 4-formylthiophene-2-carbonitrile 
• 1364268-16-5 1-(5-bromothiophen-3-yl)-N,N-dimethylmethanamine 
• 1364267-14-0 (+/-)-methyl 4-(3-amino-6-(4-((dimethylamino)methyl)thiophen-2-yl)pyrazin-2-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate 
• 1364268-54-1 (+/-)-4-(3-amino-6-(4-((dimethylamino)methyl)thiophen-2-yl)pyrazin-2-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide 
• 1364267-90-2 (+/-)-methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate 
• 1364267-93-5 (R)-methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate 
• 1364267-95-7 methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-methoxybenzoate 
• 1364267-98-0 methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-((4-methoxybenzyl)oxy)benzoate 
• 1364268-95-0 (+/-)-4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide 
• 1364268-99-4 (R)-4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide 
• 1364269-03-3 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-methoxybenzamide 
• 1364268-01-8 methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-hydroxybenzoate 
• 1364268-04-1 C₂₅H₂₄F₃N₃O₃S 
• 1364268-07-4 (+/-)-(Z)-methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-((5,5,5-trifluoropent-3-en-2-yl)oxy)benzoate 

Relevant academic research and scientific papers

Novel intramolecular π-π-interaction in a BODIPY system by oxidation of a single selenium center: geometrical stamping and spectroscopic and spectrometric distinctions

A new BODIPY system displaying an intramolecular π-π-interaction was synthesized and studied. When the selenium center was oxidized, the substituted phenyl group undergoes π-π stacking with one side of the BODIPY core. The oxidized form showed, not only a down-field shift in the NMR peak, but also splitting due to geometrical changes that arise when going from Cs to C1. The compound was characterized by X-ray diffraction; DFT methods helped elucidate the influence of the unexpected π-π stack and its connection to the photophysical properties imparted by the Se oxidation.

ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF

The present invention relates to isoxazolidines of formula I and their use as receptor-interacting protein kinase 1 inhibitors, for example in the treatment of diseases and disorders mediated by RIP kinase (1) such as rheumatoid arthritis (RA), psoriasis, inflammatory bowel disease (IBD), Crohn's disease or ulcerative colitis.

IN-FLOW PHOTOOXYGENATION OF AMINOTHIENOPYRIDINONES GENERATES NOVEL PTP4A3 PHOSPHATASE INHIBITORS

The disclosure provides compounds that inhibit protein tyrosine phosphatase, such as protein tyrosine phosphatase 4A3 (PTP4A3). The disclosure also provides pharmaceutical compositions, uses, and methods of using the compounds, such as in the treatment of cancers. (I), wherein X is O or NH.

In-flow photooxygenation of aminothienopyridinones generates iminopyridinedione PTP4A3 phosphatase inhibitors

A continuous flow photooxygenation of 7-aminothieno[3,2-c]pyridin-4(5H)-ones to produce 7-iminothieno[3,2-c]pyridine-4,6(5H,7H)-diones has been developed, utilizing ambient air as the sole reactant. N-H Imines are formed as the major products, and excellent functional group tolerance and conversion on gram-scale without the need for chromatographic purification allow for facile late-stage diversification of the aminothienopyridinone scaffold. Several analogs exhibit potent in vitro inhibition of the cancer-associated protein tyrosine phosphatase PTP4A3, and the SAR supports an exploratory docking model.

COMPOUNDS AND METHODS for the inhibition of HDAC

Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, Z, L and n are as defined herein, and methods of making and using the same.

A benzodithiophene-based semiconducting polymer for organic thin film transistor

Benzodithiophene based organic semiconducting polymer was designed and synthesized by stille coupling reaction. The structure of polymer was confirmed by NMR and IR. The weight average molecular weight (Mw) of polymer was 8,400 using GPC with polydispersity index of 1.4. The thermal, optical and electrochemical properties of polymer were characterized by TGA and DSC, UV-vis absorption and cyclic voltammetry. OTFT device using PBDT-10 exhibited the mobility of 7.2 × 10-5 cm2 V-1 s -1 and Ion/Ioff of 2.41 × 103. The film morphology and crystallinity of PBDT-10, was studied using AFM and XRD.

Podands with 10-ethyl-3,7-dithienyl-10h-phenothiazine core: Synthesis and structural analysis

New podands showing substituted thiophene-2-yl groups connected to positions 3 and 7 of a central 10-ethyl-10H-phenothiazine unit were obtained in good yields by cross-coupling reaction strategies. The thiophene rings are substituted either with formyl or hydroxymethyl groups, either at position 4' or at position 5'. These podands can participate by various reactions to the enclosure of macrocycles, and the reported compounds are versatile precursors for host molecules embedding thiophene and phenothiazine moieties. The structure of the podands was investigated by NMR and MS spectra.

Preparation and properties of a novel polythiophene, poly[(3- hexyliminomethyl)thiophene] with a high regioregularity

Poly[(3-hexyliminomethyl)thiophene]s (P3HITs) were synthesized from the polymerizations of 2,5-dibromo-(hexyliminomethyl)thiophene and 5-bromo-2-iodo-3-(hexyliminomethyl)thiophene by Grignard metathesis method. The corresponding P3HITs with low regioregularity (70%) and high regioregularity (95%) were obtained, respectively. UV-vis and photoluminescence spectra of P3HIT were dependent on the regioregularity and solvent polarity. By hydrolysis of the imino groups in the side chains under acidic conditions, P3HIT was successfully converted into the polythiophene (P3TCHO) having aldehyde groups. This transformation was also performed facilely by exposing the P3HIT film to HCl gas to give the polythiophene having aldehyde moiety. The reverse way from aldehyde to imine was also successfully demonstrated by treating the film with triethylamine vapor.

CHEMICAL COMPOUNDS

The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.