2-(Pyridin-2-ylmethoxy)benzaldehyde

Base Information

• Chemical Name: 2-(Pyridin-2-ylmethoxy)benzaldehyde
• CAS No.: 54402-61-8
• Molecular Formula: C13H11NO2
• Molecular Weight: 213.236
• Hs Code.: 2933399090
• European Community (EC) Number: 839-084-6
• DSSTox Substance ID: DTXSID70354385
• Nikkaji Number: J2.121.602J
• Wikidata: Q82132478
• Mol file: 54402-61-8.mol

Synonyms:2-(pyridin-2-ylmethoxy)benzaldehyde;54402-61-8;2-(Pyridin-2-ylmethoxy)-benzaldehyde;2-[(pyridin-2-yl)methoxy]benzaldehyde;2-(2-Pyridinylmethoxy)benzaldehyde;Oprea1_845944;SCHEMBL8038110;DTXSID70354385;LWNJUMGCXIAKPI-UHFFFAOYSA-N;2-(2-pyridylmethoxy)-benzaldehyde;AMY30944;BBL012235;MFCD03110642;STK803092;AKOS000104259;VS-03246;4-(Diethylamino)benzaldehydediphenylhydrazone;BB 0259195;CS-0117248;CS-0374153;EN300-27286;2-(pyridin-2-ylmethoxy)-benzaldehyde, AldrichCPR;SR-01000315038;SR-01000315038-1;Z235344781

Chemical Property of 2-(Pyridin-2-ylmethoxy)benzaldehyde

Chemical Property:

• Boiling Point: 370.1±22.0 °C(Predicted)
• PKA: 3.95±0.12(Predicted)
• PSA: 39.19000
• Density: 1.191±0.06 g/cm3(Predicted)
• LogP: 2.47310
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 213.078978594
• Heavy Atom Count: 16
• Complexity: 220

Purity/Quality:

97% ^*data from raw suppliers

2-(pyridin-2-ylmethoxy)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C=O)OCC2=CC=CC=N2

Technology Process of 2-(Pyridin-2-ylmethoxy)benzaldehyde

There total 4 articles about 2-(Pyridin-2-ylmethoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-chloromethylpyridine hydrochloride (6959-47-3) + salicylaldehyde (90-02-8) → 2-(pyridin-2-ylmethoxy)-benzaldehyde (54402-61-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c3ob42039f

Reference yield: 83.0%

→ 2-(pyridin-2-ylmethoxy)-benzaldehyde (54402-61-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃;

Reference yield: 66.0%

2-chloromethylpyridine (4377-33-7) + salicylaldehyde (90-02-8) → 2-(pyridin-2-ylmethoxy)-benzaldehyde (54402-61-8)

Guidance literature:

salicylaldehyde; With potassium carbonate; In acetonitrile; for 0.666667h; Reflux;

2-chloromethylpyridine; With potassium iodide; In acetonitrile; for 12h; Reflux;

DOI:10.1002/ejic.201300809

upstream raw materials:

2-chloromethylpyridine hydrochloride

salicylaldehyde

2-chloromethylpyridine

Downstream raw materials:

2-(pyridin-2-ylmethoxy)-benzaldehyde oxime

C₃₀H₂₂N₂O₂

C₃₉H₃₇N₅O₃

2-(benzofuran-2-yl)pyridine