3-Matida

Base Information

• Chemical Name: 3-Matida
• CAS No.: 518357-51-2
• Molecular Formula: C8H9NO4S
• Molecular Weight: 215.23
• DSSTox Substance ID: DTXSID40439259
• Nikkaji Number: J2.939.353B
• Wikidata: Q27073742
• Pharos Ligand ID: 3XAWF7AVS82A
• ChEMBL ID: CHEMBL1322301
• Mol file: 518357-51-2.mol

Synonyms:3-MATIDA;3-methyl-aminothiophene dicarboxylic acid

Chemical Property of 3-Matida

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.652
• Boiling Point: 461.266°C at 760 mmHg
• Flash Point: 232.766°C
• PSA: 128.86000
• Density: 1.542g/cm³
• LogP: 1.53940
• Storage Temp.: Store at +4°C
• XLogP3: -1.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 215.02522894
• Heavy Atom Count: 14
• Complexity: 258

Purity/Quality:

97% ^*data from raw suppliers

3-MATIDA ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(SC(=C1)C(=O)O)C(C(=O)O)N
• Uses: 3-MATIDA is a potent mGluR-1 antagonist.

Technology Process of 3-Matida

There total 18 articles about 3-Matida which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-((S)-Amino-carbamoyl-methyl)-4-methyl-thiophene-2-carboxylic acid; hydrochloride → (+)-3-MATIDA (518357-51-2) + (-)-3-MATIDA (518357-51-2)

Guidance literature:

With hydrogenchloride; In methanol; at 0 - 20 ℃; for 6h; Title compound not separated from byproducts;

DOI:10.1016/j.farmac.2003.11.008

Reference yield:

5-((S)-Amino-carbamoyl-methyl)-4-methyl-thiophene-2-carboxylic acid; hydrochloride → (+)-3-MATIDA (518357-51-2) + (-)-3-MATIDA (518357-51-2)

Guidance literature:

With hydrogenchloride; In methanol; at 0 - 20 ℃; for 6h; Title compound not separated from byproducts;

DOI:10.1016/j.farmac.2003.11.008

Reference yield:

3-methyl-2-thiophenecarboxaldehdye (5834-16-2,699531-50-5) → (+)-3-MATIDA (518357-51-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 87 percent / 24 h / Heating

2.1: n-BuLi; TMEDA / hexane; tetrahydrofuran / 2 h / -78 °C

2.2: hexane; tetrahydrofuran; diethyl ether / 16 h / 20 °C

3.1: 8.3 g / aq. H₂SO₄

4.1: 80 percent / HCl / 36 h

5.1: 74 percent / ZnCl₂ / CH₂Cl₂; tetrahydrofuran / 48 h / -25 - -20 °C

6.1: HCl / methanol / 6 h / 0 - 20 °C

7.1: HCl / methanol / 6 h / 0 - 20 °C

With hydrogenchloride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; zinc(II) chloride; In tetrahydrofuran; methanol; hexane; dichloromethane;

DOI:10.1016/j.farmac.2003.11.008

upstream raw materials:

3-methyl-2-thiophenecarboxaldehdye

5-formyl-4-methylthiophene-2-carboxylic acid

5-formyl-4-methylthiophene-2-carboxylic acid methyl ester

1,3-dimethyl-2-(3'-methyl-2'-thienyl)imidazolidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 518357-51-2 3-MATIDA

Send

Send

Metric Ton KG G Pound L ML

Send

Send