Methyl 5-formyl-4-methylthiophene-2-carboxylate

Base Information

Chemical Name:Methyl 5-formyl-4-methylthiophene-2-carboxylate
CAS No.:391936-75-7
Molecular Formula:C₈H₈O₃S
Molecular Weight:184.216
Hs Code.:
DSSTox Substance ID:DTXSID20700974
Wikidata:Q82632514
Mol file:391936-75-7.mol

Synonyms:391936-75-7;Methyl 5-formyl-4-methylthiophene-2-carboxylate;METHYL 5-FORMYL-4-METHYL-2-THIOPHENECARBOXYLATE;SCHEMBL7431737;DTXSID20700974;MFCD04972647;AKOS006294431

Suppliers and Price of Methyl 5-formyl-4-methylthiophene-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
METHYL-5-FORMYL-4-METHYL-2-THIOPHENECARBOXYLATE 95.00%
5MG
$ 505.10

Advanced Chemicals Intermediatesced Chemicals Intermediates
5-Formyl-4-methyl-thiophene-2-carboxylicacidmethylester 95%+
5g
$ 1442.75

Acints
5-Formyl-4-methyl-thiophene-2-carboxylicacidmethylester 95%+
1g
$ 572.75

Total 1 raw suppliers

Chemical Property of Methyl 5-formyl-4-methylthiophene-2-carboxylate

Chemical Property:

Melting Point:76.3℃
PSA：71.61000
LogP:1.65560
XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:184.01941529
Heavy Atom Count:12
Complexity:193

Purity/Quality:: METHYL-5-FORMYL-4-METHYL-2-THIOPHENECARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: S24/25:Avoid contact with skin and eyes.;

MSDS Files:

Useful:

Canonical SMILES:CC1=C(SC(=C1)C(=O)OC)C=O

Technology Process of Methyl 5-formyl-4-methylthiophene-2-carboxylate

There total 4 articles about Methyl 5-formyl-4-methylthiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 67-56-1
methanol

: 391936-74-6
5-formyl-4-methylthiophene-2-carboxylic acid

: 391936-75-7
5-formyl-4-methylthiophene-2-carboxylic acid methyl ester

Guidance literature:: With hydrogenchloride; for 36h;
DOI:10.1016/j.farmac.2003.11.008

Reference yield:

: 5834-16-2,699531-50-5
3-methyl-2-thiophenecarboxaldehdye

: 391936-75-7
5-formyl-4-methylthiophene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 87 percent / 24 h / Heating

2.1: n-BuLi; TMEDA / hexane; tetrahydrofuran / 2 h / -78 °C

2.2: hexane; tetrahydrofuran; diethyl ether / 16 h / 20 °C

3.1: 8.3 g / aq. H₂SO₄

4.1: 80 percent / HCl / 36 h

With hydrogenchloride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; In tetrahydrofuran; hexane;
DOI:10.1016/j.farmac.2003.11.008

Reference yield:

: 391936-73-5
1,3-dimethyl-2-(3'-methyl-2'-thienyl)imidazolidine

: 391936-75-7
5-formyl-4-methylthiophene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi; TMEDA / hexane; tetrahydrofuran / 2 h / -78 °C

1.2: hexane; tetrahydrofuran; diethyl ether / 16 h / 20 °C

2.1: 8.3 g / aq. H₂SO₄

3.1: 80 percent / HCl / 36 h

With hydrogenchloride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; In tetrahydrofuran; hexane;
DOI:10.1016/j.farmac.2003.11.008