4-Aminotetrahydrothiopyran-4-carbonitrile

Base Information

• Chemical Name: 4-Aminotetrahydrothiopyran-4-carbonitrile
• CAS No.: 50289-20-8
• Molecular Formula: C6H10N2S
• Molecular Weight: 142.22
• Mol file: 50289-20-8.mol

Synonyms:4-Aminotetrahydrothiopyran-4-carbonitrile

Chemical Property of 4-Aminotetrahydrothiopyran-4-carbonitrile

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.562
• Boiling Point: 297.741°C at 760 mmHg
• PKA: 3.59±0.20(Predicted)
• Flash Point: 133.869°C
• Density: 1.172g/cm³

Purity/Quality:

98% ^*data from raw suppliers

4-aminothiane-4-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Aminotetrahydrothiopyran-4-carbonitrile

There total 5 articles about 4-Aminotetrahydrothiopyran-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Tetrahydrothiopyran-4-one (1072-72-6) + potassium cyanide (151-50-8) → 4-amino-tetrahydro-2H-thiopyran-4-carbonitrile (50289-20-8)

Guidance literature:

Tetrahydrothiopyran-4-one; potassium cyanide; With ammonium chloride; In methanol; water; Heating / reflux;

With sodium hydroxide; In methanol; water; at 20 ℃;

Reference yield: 86.0%

Tetrahydrothiopyran-4-one (1072-72-6) → 4-amino-tetrahydro-2H-thiopyran-4-carbonitrile (50289-20-8)

Guidance literature:

With ammonium chloride; In methanol; water;

Reference yield:

Tetrahydrothiopyran-4-one (1072-72-6) + trimethylsilyl cyanide (7677-24-9) → 4-amino-tetrahydro-2H-thiopyran-4-carbonitrile (50289-20-8)

Guidance literature:

Tetrahydrothiopyran-4-one; With ammonia; In ethanol; at 0 ℃; for 4h;

trimethylsilyl cyanide; In ethanol; at 0 - 20 ℃; for 5h;

upstream raw materials:

Tetrahydrothiopyran-4-one

potassium cyanide

4-(4-imino-2-oxo-8-oxa-1,3-diazaspiro[4.5]decan-3-yl)-2-(trifluoromethyl)-benzonitrile

trimethylsilyl cyanide

Downstream raw materials:

4-aminotetrahydrothiopyran-4-carboxylic acid

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