1-(2,4,6-TRIHYDROXYPHENYL)-2-P-TOLYLETHANONE

Base Information

• Chemical Name: 1-(2,4,6-TRIHYDROXYPHENYL)-2-P-TOLYLETHANONE
• CAS No.: 59108-68-8
• Molecular Formula: C15H14O4
• Molecular Weight: 258.274
• Mol file: 59108-68-8.mol

Synonyms:1-(2,4,6-TRIHYDROXYPHENYL)-2-P-TOLYLETHANONE

Chemical Property of 1-(2,4,6-TRIHYDROXYPHENYL)-2-P-TOLYLETHANONE

Chemical Property:

• Melting Point: 205–206°C (anhydrous)
• PSA: 77.76000
• LogP: 2.53720

Purity/Quality:

98%Min ^*data from raw suppliers

1-(2,4,6-Trihydroxyphenyl)-2-p-tolylethanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2,4,6-TRIHYDROXYPHENYL)-2-P-TOLYLETHANONE

There total 3 articles about 1-(2,4,6-TRIHYDROXYPHENYL)-2-P-TOLYLETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

(4-methylphenyl)acetonitrile (2947-61-7) + 3,5-dihydroxyphenol (108-73-6) → 2-(4''-methylphenyl)-2',4',6'-trihydroxyacetophenone (59108-68-8)

Guidance literature:

(4-methylphenyl)acetonitrile; 3,5-dihydroxyphenol; With hydrogenchloride; zinc(II) chloride; In diethyl ether; at 0 ℃;

With water; for 2h; Reflux;

DOI:10.1155/2018/4032105

Reference yield: 52.0%

3,5-dihydroxyphenol (108-73-6) + 4-tolylacetic acid (622-47-9) → 2-(4''-methylphenyl)-2',4',6'-trihydroxyacetophenone (59108-68-8)

Guidance literature:

With boron trifluoride diethyl etherate; at 85 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.carres.2019.107756

Reference yield:

3,5-dihydroxyphenol (108-73-6) → 2-(4''-methylphenyl)-2',4',6'-trihydroxyacetophenone (59108-68-8)

Guidance literature:

With hydrogenchloride; diethyl ether; zinc(II) chloride; und Kochen des Reaktionsprodukts mit Wasser;

upstream raw materials:

3,5-dihydroxyphenol

(4-methylphenyl)acetonitrile

4-tolylacetic acid

Downstream raw materials:

5,7-dihydroxy-3-tolyl-4H-chromen-4-one

Refernces

• 1、 Hamza Sherif, Salah,Gebreyohannes, BerihuTekluu. "Synthesis, Characterization, and Antioxidant Activities of Genistein, Biochanin A, and Their Analogues". . . Retrieved 2018/04/30.