1-(Phenylsulfonyl)indole-3-sulfonyl chloride

Base Information

• Chemical Name: 1-(Phenylsulfonyl)indole-3-sulfonyl chloride
• CAS No.: 535930-73-5
• Molecular Formula: C14H10ClNO4S2
• Molecular Weight: 355.82
• Hs Code.: 2933990090
• Mol file: 535930-73-5.mol

Synonyms:1-(Phenylsulfonyl)indole-3-sulfonyl chloride

Chemical Property of 1-(Phenylsulfonyl)indole-3-sulfonyl chloride

Chemical Property:

• Vapor Pressure: 1.1E-12mmHg at 25°C
• Refractive Index: 1.673
• Boiling Point: 562.6°C at 760 mmHg
• Flash Point: 294.1°C
• PSA: 89.97000
• Density: 1.52g/cm³
• LogP: 4.96740
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-(Phenylsulfonyl)indole-3-sulfonyl chloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(Phenylsulfonyl)indole-3-sulfonyl chloride

There total 1 articles about 1-(Phenylsulfonyl)indole-3-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-benzenesulfonylindole (40899-71-6) → 1-(phenylsulfonyl)-1H-indole-3-sulfonyl chloride (535930-73-5)

Guidance literature:

With chlorosulfonic acid; In acetonitrile; at 0 - 40 ℃;

DOI:10.1248/cpb.57.591

Reference yield: 93.0%

1-(phenylsulfonyl)-1H-indole-3-sulfonyl chloride (535930-73-5) + morpholine (110-91-8,99108-56-2) → 3-(morpholine-4-sulfonyl)-1-phenylsulfonyl-1H-indole (881406-21-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.tet.2005.11.062

Reference yield: 91.0%

1-(phenylsulfonyl)-1H-indole-3-sulfonyl chloride (535930-73-5) + 1H-imidazole (288-32-4) → 3-(imidazole-1-sulfonyl)-1-phenylsulfonyl-1H-indole

Guidance literature:

In dichloromethane; at 20 ℃; for 21h;

DOI:10.1016/j.tet.2005.11.062

upstream raw materials:

1-benzenesulfonylindole

Downstream raw materials:

3-(morpholine-4-sulfonyl)-1-phenylsulfonyl-1H-indole

N,N'-[4,4'-(furan-2,5-diyl)bis(4,1-phenylene)]bis[1-(phenylsulfonyl)-1H-indole-3-sulfonamide]

N,N'-[4,4'-(furan-2,5-diyl)bis(3-methyl-4,1-phenylene)]bis[1-(phenylsulfonyl)-1H-indole-3-sulfonamide]

Refernces

• 1、 Janosik, Tomasz,Shirani, Hamid,Wahlstr?m, Niklas,Malky, Ilham,Stensland, Birgitta,Bergman, Jan. "Efficient sulfonation of 1-phenylsulfonyl-1H-pyrroles and 1-phenylsulfonyl-1H-indoles using chlorosulfonic acid in acetonitrile". . p. 1699 - 1707. Retrieved 2007/10/03.