7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide

Base Information

• Chemical Name: 7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide
• CAS No.: 76488-09-0
• Molecular Formula: C₁₆H₁₂ClFN₄O
• Molecular Weight: 330.749
• Mol file: 76488-09-0.mol

Synonyms:7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide

Chemical Property of 7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide

There total 2 articles about 7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine (76488-35-2) → 7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide (76488-09-0)

Guidance literature:

With ammonia; In ethanol; Ambient temperature; overnight;

DOI:10.1002/jhet.5570200313

Reference yield:

7-chloro-5-(2-fluorophenyl)-2-nitromethylene-1,3-dihydro-2H-1,4-benzodiazepine (59467-63-9) → 7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide (76488-09-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / NaNO₂ / acetic acid / 0.25 h / Ambient temperature

2: 69 percent / NH₃ / ethanol / Ambient temperature; overnight

With ammonia; sodium nitrite; In ethanol; acetic acid;

DOI:10.1002/jhet.5570200313

Reference yield: 65.0%

7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide (76488-09-0) → 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide (76488-22-7)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; ethanol; Ambient temperature; overnight;

DOI:10.1002/jhet.5570200313

upstream raw materials:

7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine

7-chloro-5-(2-fluorophenyl)-2-nitromethylene-1,3-dihydro-2H-1,4-benzodiazepine

Downstream raw materials:

7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide