3-(3,5-DIMETHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

Base Information

• Chemical Name: 3-(3,5-DIMETHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER
• CAS No.: 54901-09-6
• Molecular Formula: C13H18O4
• Molecular Weight: 238.284
• Hs Code.: 2918990090
• Mol file: 54901-09-6.mol

Synonyms:3-(3,5-DIMETHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

Chemical Property of 3-(3,5-DIMETHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.000118mmHg at 25°C
• Refractive Index: 1.492
• Boiling Point: 335.6°C at 760 mmHg
• Flash Point: 145.7°C
• PSA: 44.76000
• Density: 1.067
• LogP: 2.19950
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl3-(3,5-Dimethoxyphenyl)propionate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 3-(3,5-Dimethoxyphenyl)propionate is a reagent used in the synthesis of highly potent pan-fibroblast growth receptor inhibitors. Also a reagent in the preparation of selective inhibitors of the FGFR tyrosine kinase.

Technology Process of 3-(3,5-DIMETHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

There total 4 articles about 3-(3,5-DIMETHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 3,5-dimethoxycinnamate (29584-64-3,42174-79-8) → 3-(3,5-dimethoxyphenyl)propionic acid ethyl ester (54901-09-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 4h;

DOI:10.1081/SCC-120004271

Reference yield: 98.7%

(E)-ethyl 3-(3,5-dimethoxyphenyl)acrylate (42174-79-8,29584-64-3) → 3-(3,5-dimethoxyphenyl)propionic acid ethyl ester (54901-09-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 6h;

DOI:10.1016/j.bmcl.2016.04.028

Reference yield: 97.4%

ethanol (64-17-5) + 3-(3,5-dimethoxyphenyl)propionic acid (717-94-2) → 3-(3,5-dimethoxyphenyl)propionic acid ethyl ester (54901-09-6)

Guidance literature:

With thionyl chloride; at 20 ℃; for 12h; Cooling with ice;

upstream raw materials:

(E)-ethyl 3-(3,5-dimethoxyphenyl)acrylate

ethyl 3,5-dimethoxycinnamate

3,5-dimethoxybenzaldehdye

ethanol

Downstream raw materials:

5-(3,5-dimethoxyphenyl)-3-oxopentanenitrile

3-(3,5-dimethoxyphenylethyl)-1H-pyrazol-5-amine

N₄-(3-(3,5-dimethoxyphenylethyl)-1H-pyrazol-5-yl)-N₂-((3-methylisoxazol-5-yl)methyl)pyrimidine-2,4-diamine